CAS 128219-85-2

Inosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description:

Inosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a synthetic nucleoside derivative characterized by its complex structure, which includes an inosine base modified at the 5' and 3' positions. The presence of a bis(4-methoxyphenyl)phenylmethyl group at the 5' position enhances its stability and solubility, while the 2'-O-methyl modification contributes to its resistance to enzymatic degradation. The 3' position features a cyanoethyl phosphoramidite moiety, which is commonly utilized in oligonucleotide synthesis, allowing for the incorporation of this compound into nucleic acid sequences. This substance is typically used in biochemical research and applications involving nucleic acid chemistry, such as the synthesis of modified RNA or DNA. Its unique structural features may also impart specific biological activities, making it a subject of interest in medicinal chemistry and drug development. As with many phosphoramidites, it is sensitive to moisture and should be handled under anhydrous conditions to maintain its integrity.

Formula: C₄₁H₄₉N₆O₈P

InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-36-34(54-40(37(36)51-7)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37-,40-,56?/m1/s1

InChI key: InChIKey=PVFNTYBGWVZMCX-HLHZJIEZSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@@H](O1)N2C3=C(N=C2)C(=O)N=CN3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• 2'-O-Methyl-5'-O-DMT-Inosine-3'-CE-Phosphoramidite
• Inosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 5'-Dimethoxytrityl-Inosine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• 2'-O-METHYL-I CEP
• 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylinosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 5'-O-DMT-2'-O-methylinosine 3'-CE phosphoramidite
• 2'-O-Methyl Inosine Phosphoramidite
• 5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Inosine-3'-CE-Phosphoramidite
• 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(6-oxo-3H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite

CAS: 128219-85-2

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite

Purity: 98%

Molecular weight: 784.84g/mol

Ref: 54-OR1005617

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite

CAS: 128219-85-2

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a Nucleoside Phosphoramidite.

Formula: C₄₁H₄₉N₆O₈P

Color and Shape: Solid

Molecular weight: 784.84

Ref: TM-TNU1561

2′-O-Methyl-5′-O-dmt-inosine-3′-CE-phosphoramidite

CAS: 128219-85-2

Purity: 98%

Molecular weight: 784.33

Ref: 10-F556669

2'-O-Methyl Inosine Phosphoramidite

Controlled Product

CAS: 128219-85-2

Applications 2'-O-Methyl Inosine Phosphoramidite is used as a heteroduplex probe in discriminating a single-nucleotide difference in RNA.
References Matsumoto, Katsuhiko. et al., Chem. Eur. J. 19, 5034-5040(2013);

Formula: C₄₁H₄₉N₆O₈P

Color and Shape: Neat

Molecular weight: 784.837

Ref: TR-M235780

5'-O-DMT-2'-O-methylinosine 3'-CE phosphoramidite

CAS: 128219-85-2

5'-O-DMT-2'-O-methylinosine 3'-CE phosphoramidite is a novel modified nucleoside analog. It is synthesized from the corresponding ribonucleoside and deoxyribonucleoside by means of a high-yield, convergent method. This compound has antiviral activity against herpes simplex virus type 1 (HSV-1) and cytomegalovirus (CMV) in vitro. 5'-O-DMT-2'-O-methylinosine 3'-CE phosphoramidite also exhibits anticancer activities in cell culture.

Formula: C₄₁H₄₉N₆O₈P

Purity: Min. 95%

Molecular weight: 784.86 g/mol

Ref: 3D-PD08575