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CAS 128255-45-8

:

4-hydroxytamoxifen beta-glucuronide

Description:
4-Hydroxytamoxifen beta-glucuronide is a metabolite of tamoxifen, a selective estrogen receptor modulator commonly used in the treatment of estrogen receptor-positive breast cancer. This compound is characterized by the presence of a hydroxyl group at the fourth position of the tamoxifen structure, which enhances its biological activity. The beta-glucuronide moiety indicates that it is conjugated with glucuronic acid, a process that typically occurs in the liver and aids in the detoxification and excretion of drugs. This conjugation increases the solubility of the compound in water, facilitating its elimination from the body. 4-Hydroxytamoxifen itself exhibits anti-estrogenic properties, and its glucuronide form may influence the pharmacokinetics and pharmacodynamics of tamoxifen therapy. The compound is of interest in pharmacological studies, particularly in understanding the metabolism of tamoxifen and its efficacy in cancer treatment. Its CAS number, 128255-45-8, is a unique identifier that can be used to find more detailed information in chemical databases.
Formula:C32H37NO8
InChI:InChI=1/C32H37NO8/c1-4-25(21-11-7-5-8-12-21)26(22-15-17-23(18-16-22)39-20-19-33(2)3)32(38)28(35)27(34)31(41-29(32)30(36)37)40-24-13-9-6-10-14-24/h5-18,27-29,31,34-35,38H,4,19-20H2,1-3H3,(H,36,37)/b26-25-/t27-,28-,29-,31-,32+/m1/s1
Synonyms:
  • 4-Htbg
  • phenyl 4-C-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]-beta-D-glucopyranosiduronic acid
  • 4-Hydroxytamoxifen beta-glucuronide
  • β-D-Glucopyranosiduronic acid, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenyl
  • (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
  • 4-[(1Z)-1-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenyl β-D-Glucopyranosiduronic Acid
  • (Z)-4-[1-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenyl β-D-Glucopyranosiduronic Acid
  • (Z)-4-Hydroxy TaMoxifen O-β-D-Glucuronide
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Found 2 products.
  • (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide
    TLC
    + Info

    (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide

    CAS:
    Formula:C32H37NO8
    Molecular weight:563.65

    Ref: 4Z-T-0136

    5mg
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    10mg
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    25mg
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    50mg
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    100mg
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  • (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
    TRC
    + Info

    (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)

    Controlled Product
    CAS:
    <p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>
    Formula:C32H37NO8
    Purity:~90%
    Color and Shape:Neat
    Molecular weight:563.64

    Ref: TR-H954765

    25mg
    1,987.00€
    2500µg
    315.00€