CAS 128270-60-0

Bivalirudin

Description:

Bivalirudin is a synthetic peptide that functions as a direct thrombin inhibitor, primarily used as an anticoagulant in clinical settings, particularly during percutaneous coronary interventions. Its structure consists of 20 amino acids, and it is derived from the hirudin peptide found in leeches. Bivalirudin exhibits a high affinity for thrombin, effectively preventing the conversion of fibrinogen to fibrin, which is crucial in the clotting process. The substance is administered via intravenous injection and has a relatively short half-life, necessitating careful monitoring of anticoagulation levels during treatment. Bivalirudin is characterized by its stability in the bloodstream and its ability to provide rapid anticoagulation with a predictable pharmacokinetic profile. It is often favored over traditional anticoagulants due to its lower risk of inducing thrombocytopenia and its ease of use in patients with varying renal function. Overall, Bivalirudin represents a significant advancement in anticoagulant therapy, particularly in acute coronary syndrome management.

Formula: C₉₈H₁₃₈N₂₄O₃₃

InChI: InChI=1/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

Synonyms:

• L-leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-
• D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine
• Bivalirudin,TFA
• Bivalirudin Trifluoroacetate

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a highly specific and reversible direct thrombin inhibitor.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: 98.9%

Color and Shape: White

Molecular weight: 2180.32

Ref: 01-4049766

Bivalirudin

CAS: 128270-60-0

Cardiovascular drugs, not elsewhere specified or included

Formula: C₉₈H₁₃₈N₂₄O₃₃

Color and Shape: White Off-White Powder

Molecular weight: 2178.98581

Ref: 45-1076013

L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 2180.2853

Ref: IN-DA000XXZ

Bivalirudin

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Molecular weight: 2180.29

Ref: 7W-GP4765

Bivalirudin

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Color and Shape: White To Off-White Solid

Molecular weight: 2180.32

Ref: 4Z-PB-122001

Bivalirudin Trifluoroacetate

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 2180.29

Ref: BP-BPPG010

Bivalirudin

CAS: 128270-60-0

Bivalirudin

Color and Shape: Powder

Molecular weight: 2,180.29g/mol

Ref: 54-BITP1474

Bivalirudin

CAS: 128270-60-0

Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: 98.8% - >99.99%

Color and Shape: White To Off-White Powder

Molecular weight: 2180.29

Ref: TM-T5519

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a synthetic cyclic peptide that binds to the ATP-binding cassette transporter and inhibits the activity of the proteolytic enzyme, angiotensin-converting enzyme (ACE). ACE inhibition prevents the conversion of angiotensin I to angiotensin II. Bivalirudin has been shown to be effective in reducing mortality in patients with acute coronary syndrome or undergoing percutaneous coronary intervention. It has also been shown to have pharmacokinetic properties that are similar to those of heparin. The drug has a low dose and is not associated with an increased risk of bleeding. Bivalirudin is an inhibitor and can cause drug interactions when combined with other drugs that are inhibitors or substrates for this type of transporter.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: Min. 95%

Molecular weight: 2,180.33 g/mol

Ref: 3D-BIV-3767-PI

Bivalirudin

CAS: 128270-60-0

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purity: Min. 95%

Color and Shape: White Solid

Molecular weight: 2178.98581

Ref: 3D-FB29604

Bivalirudin 1-11 Fragment Trifluoroacetic Acid Salt

Controlled Product

CAS: 128270-60-0

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Formula: C₄₃H₆₃N₁₅O₁₅·(C₂HF₃O₂)x

Color and Shape: Neat

Molecular weight: 1030.0511402

Ref: TR-B591640