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CAS 128345-62-0

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Ranitidine bismuth citrate

Description:
Ranitidine bismuth citrate is a pharmaceutical compound primarily used for its gastroprotective properties, particularly in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD). It combines ranitidine, an H2 receptor antagonist that reduces stomach acid production, with bismuth, which has mucosal protective effects. This combination enhances the therapeutic efficacy by not only decreasing acid secretion but also promoting the healing of the gastric mucosa. The compound is typically administered in oral form and is known for its ability to form a protective barrier over the gastric lining, thereby reducing irritation from gastric acid and promoting ulcer healing. Ranitidine bismuth citrate is also recognized for its antimicrobial activity against Helicobacter pylori, a common bacterium associated with peptic ulcers. While it has been widely used, concerns regarding the safety of ranitidine have led to regulatory scrutiny and market withdrawal in some regions. Overall, its unique dual action makes it a valuable option in gastrointestinal therapy, although its use may be limited by safety considerations.
Formula:C13H22N4O3S·C6H8O7·Bi
InChI:InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);
InChI key:InChIKey=KMNPCCNMXHDTHJ-UHFFFAOYSA-N
SMILES:C(N(C)C)C=1OC(CSCCNC(=CN(=O)=O)NC)=CC1.C(CC(O)=O)(CC(O)=O)(C(O)=O)O.[Bi]
Synonyms:
  • 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-, compd. with 2-hydroxy-1,2,3-propanetricarboxylic acid bismuth(3+) salt (1:1:1)
  • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3+) salt, compd. with N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine (1:1:1)
  • Gastrimuto
  • Gr 122311X
  • Pylorid
  • Ranitidine Bismuth Citrate
  • Ranitidine bismutrex
  • Rantidinebismuthcitrate
  • Tritec
  • bismuth(3+) 2-hydroxypropane-1,2,3-tricarboxylate - (Z)-N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine (1:1)
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