CAS 128446-34-4: Hydroxypropyl-gamma-cyclodextrin

Description: Hydroxypropyl-gamma-cyclodextrin (HPγCD) is a modified cyclic oligosaccharide derived from gamma-cyclodextrin, which consists of seven glucose units linked by α-1,4-glycosidic bonds. The hydroxypropyl modification enhances its solubility in water and improves its ability to form inclusion complexes with various hydrophobic compounds, making it valuable in pharmaceutical, food, and cosmetic applications. HPγCD exhibits low toxicity and is generally recognized as safe (GRAS), which allows for its use in various formulations. Its unique structure provides a hydrophilic exterior and a hydrophobic cavity, facilitating the encapsulation of guest molecules. This property is particularly beneficial for enhancing the solubility and stability of poorly soluble drugs, thereby improving their bioavailability. Additionally, HPγCD can influence the release profiles of encapsulated substances, making it a versatile excipient in drug delivery systems. Its ability to form stable complexes also extends to flavor and fragrance compounds, enhancing their stability and release in food and cosmetic products. Overall, HPγCD is a multifunctional compound with significant applications across multiple industries.

Formula: C₆₃H₁₁₀O₄₅

InChI: InChI:1S/C63H110O45/c1-19(67)9-88-14-27-51-38(78)46(86)62(99-27)108-55-31(18-92-13-23(5)71)100-63(47(87)39(55)79)107-54-30(17-91-12-22(4)70)97-60(44(84)36(54)76)103-50-26(8-66)95-58(42(82)34(50)74)105-52-28(15-89-10-20(2)68)98-61(45(85)37(52)77)106-53-29(16-90-11-21(3)69)96-59(43(83)35(53)75)102-49-25(7-65)93-56(40(80)32(49)72)101-48-24(6-64)94-57(104-51)41(81)33(48)73/h19-87H,6-18H2,1-5H3

Synonyms:

• Hydroxypropyl-Gamma-Cyclodextrin (Hgc) 4 5% W/V Solution In H2O
• Hydroxypropyl-Gamma-Cyclodextrin, Ms=0.6
• .gamma.-Cyclodextrin, 2-hydroxypropyl ethers
• Cavasol(R)W8

γ-Cyclodextrin, 2-hydroxypropyl ethers

CAS: 128446-34-4

• Formula: C₇H₆FNO₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 155.1264

(2-Hydroxypropyl)-γ-cyclodextrin

CAS: 128446-34-4

• Formula: C₄₈H₈₀nO₄₀·(C₃H₇O)n
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 1297.2 + n·(58.1)

(2-Hydroxypropyl)-γ-cyclodextrin (DS~4.5)

CAS: 128446-34-4

• Purity: >98%
• Color and Shape: Solid

(2-Hydroxypropyl)-gamma-cyclodextrin (Technical Grade)

CAS: 128446-34-4

Applications (2-Hydroxypropyl)-γ-cyclodextrin is used in the solubilization of macromolecules and in cell culture applications. Similar …

• Formula: C₆H₈N₂O
• Color and Shape: Neat

(2-Hydroxypropyl)-gamma-cyclodextrin

CAS: 128446-34-4

This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring …

• Purity: 98 To 102%
• Color and Shape: Powder