CAS 128446-34-4

Hydroxypropyl-gamma-cyclodextrin

Description:

Hydroxypropyl-gamma-cyclodextrin (HPγCD) is a modified cyclic oligosaccharide derived from gamma-cyclodextrin, which consists of seven glucose units linked by α-1,4-glycosidic bonds. The hydroxypropyl modification enhances its solubility in water and improves its ability to form inclusion complexes with various hydrophobic compounds, making it valuable in pharmaceutical, food, and cosmetic applications. HPγCD exhibits low toxicity and is generally recognized as safe (GRAS), which allows for its use in various formulations. Its unique structure provides a hydrophilic exterior and a hydrophobic cavity, facilitating the encapsulation of guest molecules. This property is particularly beneficial for enhancing the solubility and stability of poorly soluble drugs, thereby improving their bioavailability. Additionally, HPγCD can influence the release profiles of encapsulated substances, making it a versatile excipient in drug delivery systems. Its ability to form stable complexes also extends to flavor and fragrance compounds, enhancing their stability and release in food and cosmetic products. Overall, HPγCD is a multifunctional compound with significant applications across multiple industries.

Formula: C₆₃H₁₁₀O₄₅

InChI: InChI:1S/C63H110O45/c1-19(67)9-88-14-27-51-38(78)46(86)62(99-27)108-55-31(18-92-13-23(5)71)100-63(47(87)39(55)79)107-54-30(17-91-12-22(4)70)97-60(44(84)36(54)76)103-50-26(8-66)95-58(42(82)34(50)74)105-52-28(15-89-10-20(2)68)98-61(45(85)37(52)77)106-53-29(16-90-11-21(3)69)96-59(43(83)35(53)75)102-49-25(7-65)93-56(40(80)32(49)72)101-48-24(6-64)94-57(104-51)41(81)33(48)73/h19-87H,6-18H2,1-5H3

InChI key: YPWZFSMZSNIVAQ-UHWSPLBMSA-N

SMILES: CC(COC[C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CO)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)CO)CO)O)O)O

Synonyms:

• Hydroxypropyl-Gamma-Cyclodextrin (Hgc) 4 5% W/V Solution In H2O
• Hydroxypropyl-Gamma-Cyclodextrin, Ms=0.6
• .gamma.-Cyclodextrin, 2-hydroxypropyl ethers
• Cavasol(R)W8

(2-Hydroxypropyl)-γ-cyclodextrin

CAS: 128446-34-4

Formula: C₇H₆FNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 155.1264

Ref: IN-DA000Y46

(2-Hydroxypropyl)-γ-cyclodextrin

CAS: 128446-34-4

Formula: C₄₈H₈₀nO₄₀·(C₃H₇O)n

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 1297.2 + n·(58.1)

Ref: 7W-GX9244

HGC

CAS: 128446-34-4

(2-Hydroxypropyl)-γ-Cyclodextrin

Purity: 98%

Ref: IN-DG229214

(2-Hydroxypropyl)-γ-cyclodextrin (DS~4.5)

CAS: 128446-34-4

(2-Hydroxypropyl)-γ-cyclodextrin (DS~4.5)

Purity: >98%

Color and Shape: Solid-Powder

Ref: 54-BICY1008

(2-Hydroxypropyl)-γ-cyclodextrin (Technical Grade)

CAS: 128446-34-4

Applications (2-Hydroxypropyl)-γ-cyclodextrin is used in the solubilization of macromolecules and in cell culture applications. Similar to β-Cyclodextrin (C987830), however can work with larger molecules.
References Motoyama, A. et al.: J. Pharmac. Biomed. Anal., 28, 97 (2002); Nakamura, N. et al. Biotechnol. Bioeng., 19, 87 (1977); Riddle, L. A. et al.: J. Chrom. Sci., 45, 330 (2007);

Formula: C₇H₆FNO₂

Color and Shape: Neat

Molecular weight: 155.13

Ref: TR-H952120

(2-Hydroxypropyl)-gamma-cyclodextrin

CAS: 128446-34-4

This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring a larger cavity size than α- and β-cyclodextrins. This structural characteristic allows γ-CDs to form inclusion complexes with a wider range of guest molecules, making it particularly versatile in various industries. In the food sector, it is used as a carrier and stabilizer for flavors, fat-soluble vitamins, and polyunsaturated fatty acids, protecting volatile compounds from evaporation. In pharmaceuticals, it enhances the solubility and bioavailability of poorly water-soluble drugs and, thanks to its larger ring size, allows for the encapsulation of larger molecules or even entire drug molecules. γ-CDs and derivatives are also used for environmental remediation and, in analytical chemistry, for the extraction and concentration of target substances.

Purity: 98 To 102%

Color and Shape: Powder

Ref: 3D-OH11987

(2-Hydroxypropyl)-γ-Cyclodextrin

CAS: 128446-34-4

Purity: 98%

Color and Shape: Solid

Molecular weight: 0

Ref: 10-F555497