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CAS 128506-29-6

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5'-Thymidylic acid, 3'-azido-3'-deoxy-, monosodium salt

Description:
5'-Thymidylic acid, 3'-azido-3'-deoxy-, monosodium salt, commonly referred to as AZT (azidothymidine) in its active form, is a nucleoside analog used primarily in the treatment of HIV/AIDS. This compound features a thymidine backbone with an azido group at the 3' position, which impedes DNA synthesis by terminating the elongation of the DNA strand during replication. The monosodium salt form enhances its solubility in aqueous solutions, making it suitable for pharmaceutical applications. Its molecular structure includes a ribose sugar, a phosphate group, and the azido modification, which contributes to its antiviral properties. AZT is known for its ability to inhibit reverse transcriptase, an enzyme critical for the replication of retroviruses. The compound is typically administered in a therapeutic context, and its efficacy is often evaluated in conjunction with other antiretroviral agents. As with many nucleoside analogs, AZT can exhibit side effects, including hematological toxicity, necessitating careful monitoring during treatment.
Formula:C10H14N5O7PNa
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Found 2 products.
  • 3'-Azido-3'-deoxythymidine 5’-Monophosphate Sodium Salt
    TRC
    + Info

    3'-Azido-3'-deoxythymidine 5’-Monophosphate Sodium Salt

    Controlled Product
    CAS:
    <p>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br>References Brehm, J., et al.: Biochem., 47, 14020 (2008), von Kleist, M., et al.: Eur. J. Pharm. Sci., 36, 532 (2009),<br></p>
    Formula:C10H13N5O7P·Na
    Color and Shape:Neat
    Molecular weight:369.20

    Ref: TR-A825070

    10mg
    263.00€
    100mg
    1,742.00€
  • 3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt
    Biosynth
    + Info

    3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt

    CAS:
    <p>3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt is a synthetic nucleoside that is structurally related to thymidine. It has antiviral and anticancer properties, as well as the potential for use in gene therapy. 3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt is active against herpes simplex virus type 1 (HSV-1) and HSV-2, human immunodeficiency virus type 1 (HIV-1), human papillomavirus types 16 and 18 (HPV), Epstein Barr Virus (EBV), and cytomegalovirus (CMV). 3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt inhibits the production of HIV by preventing the viral reverse transcriptase from synthesizing DNA from RNA.</p>
    Formula:C10H13N5NaO7P
    Purity:Min. 95%
    Molecular weight:369.23 g/mol

    Ref: 3D-NA06327

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