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CAS 128531-73-7

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2',3'-dideoxy-2'-fluoroadenosine triphosphate

Description:
2',3'-Dideoxy-2'-fluoroadenosine triphosphate (commonly abbreviated as F-ATP) is a modified nucleotide that serves as an important tool in biochemical research, particularly in studies involving nucleic acid synthesis and enzyme activity. This compound is characterized by the presence of a fluorine atom at the 2' position of the ribose sugar, along with the absence of a hydroxyl group at the 2' and 3' positions, which distinguishes it from standard ATP. The modification imparts unique properties, such as altered binding affinity to enzymes and potential inhibition of polymerases, making it useful in studying mechanisms of DNA and RNA synthesis. F-ATP is typically used in various applications, including nucleotide incorporation studies, as well as in the development of antiviral and anticancer therapies. Its CAS number, 128531-73-7, allows for precise identification in chemical databases. Overall, 2',3'-dideoxy-2'-fluoroadenosine triphosphate is a valuable compound in molecular biology and medicinal chemistry, providing insights into nucleic acid interactions and enzymatic processes.
Formula:C10H15FN5O11P3
InChI:InChI=1/C10H15FN5O11P3/c11-6-1-5(2-24-29(20,21)27-30(22,23)26-28(17,18)19)25-10(6)16-4-15-7-8(12)13-3-14-9(7)16/h3-6,10H,1-2H2,(H,20,21)(H,22,23)(H2,12,13,14)(H2,17,18,19)/t5-,6-,10+/m0/s1
Synonyms:
  • 2'-F-Ddatp
  • 9-(2,3-Dideoxy-2-fluoro-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-threo-pentofuranosyl)-9H-purin-6-amine
  • 9H-Purin-6-amine, 9-(2,3-dideoxy-2-fluoro-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-threo-pentofuranosyl)-
  • 9-[2,3-dideoxy-2-fluoro-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-beta-D-threo-pentofuranosyl]-9H-purin-6-amine
  • 2',3'-Dideoxy-2'-fluoroadenosine triphosphate
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