CAS 1285539-85-6

rel-N-[2-[[(3R,4R)-1-[cis-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Description:

The chemical substance known as rel-N-[2-[[(3R,4R)-1-[cis-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide, with CAS number 1285539-85-6, is a complex organic compound characterized by its intricate molecular structure. It features multiple functional groups, including an amide, a trifluoromethyl group, and a benzodioxole moiety, which contribute to its potential biological activity. The presence of a pyrrolidine ring and a hydroxycyclohexyl group suggests that it may interact with biological targets, possibly influencing pharmacological properties. The stereochemistry indicated by the (3R,4R) configuration implies specific spatial arrangements that can affect the compound's reactivity and interactions. Additionally, the ethoxy group enhances its lipophilicity, potentially influencing its solubility and permeability in biological systems. Overall, this compound's unique structural features may render it of interest in medicinal chemistry, particularly in the development of therapeutic agents.

Formula: C₂₉H₃₄F₃N₃O₆

InChI: InChI=1/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28+/s2

InChI key: InChIKey=MZEOSVPWMSEFPW-KNPIBYCDNA-N

SMILES: N(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)[C@H]2CN(C[C@@H]2OCC)[C@H]3CC[C@@](O)(CC3)C=4C=C5C(=CC4)OCO5

Synonyms:

• rel-N-[2-[[(3R,4R)-1-[cis-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
• Benzamide, N-[2-[[(3R,4R)-1-[cis-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-

cis-INCB3344

CAS: 1285539-85-6

Formula: C₂₉H₃₄F₃N₃O₆

Purity: 98%

Molecular weight: 577.5920

Ref: IN-DA009C9D

INCB3344 (stereoisomer 1)

CAS: 1285539-85-6

INCB3344 is a molecule that inhibits the activity of C-C chemokine receptor, which is a protein that plays an important role in inflammatory diseases. INCB3344 has been shown to have potent inhibitory activity against the inflammatory response by inhibiting the production of cytokines and chemokines. This drug works by binding to the c-c chemokine receptor, thereby preventing it from interacting with its ligands and activating inflammatory cells. The mechanism of action of INCB3344 can be observed in deficient mice for this target tissue, where it showed no adverse effects on growth factor levels or other parameters. In addition, INCB3344 has been shown to suppress choroidal neovascularization (formation of new blood vessels) in rats and monkeys with age-related macular degeneration (AMD).

Formula: C₂₉H₃₄F₃N₃O₆

Purity: Min. 95%

Molecular weight: 577.59 g/mol

Ref: 3D-KBC53985