CAS 1285886-70-5

Retigabine-d4 Dihydrochloride

Description:

Retigabine-d4 dihydrochloride, identified by the CAS number 1285886-70-5, is a deuterated form of retigabine, a compound primarily known for its use as an anticonvulsant medication. The deuteration indicates that certain hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in pharmacokinetic studies and metabolic research. This compound typically appears as a white to off-white solid and is soluble in water and organic solvents, depending on the specific formulation. Retigabine itself functions by modulating neuronal excitability through the activation of potassium channels, particularly KCNQ2/3 channels, which helps stabilize neuronal activity and reduce seizure frequency. The dihydrochloride form suggests the presence of two hydrochloride groups, enhancing its solubility and stability. As with any chemical substance, handling should be conducted with care, following appropriate safety protocols, and its use should be guided by relevant regulatory standards.

Formula: C₁₆H₁₈FN₃O₂

Synonyms:

• D 20443-d4
• N-[2-AMino-4-[4-(fluorobenzyl-d4)aMino]phenyl]carbaMic Acid Ethyl Ester Dihydrochloride
• Retigabine-d4 Dihydrochloride
• carbaMate Dihydrochloride
• Ethyl [2-AMino-4-[[(4-fluorophenyl-d4)Methyl]aMino]phenyl]
• 1,1,2,2,2-pentadeuterioethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate

Retigabine-D4 Dihydrochloride

Controlled Product

CAS: 1285886-70-5

Applications Labelled Retigabine. A new experimental anticonvulsant drug. Anxiolytic.
References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),

Formula: C₁₆H₁₆D₄Cl₂FN₃O₂

Color and Shape: Neat

Molecular weight: 380.28

Ref: TR-R189052

Retigabine-d4 dihydrochloride

Controlled Product

CAS: 1285886-70-5

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Formula: C₁₆H₁₈FN₃O₂

Purity: Min. 95%

Molecular weight: 308.36 g/mol

Ref: 3D-KBC88670