CAS 128607-22-7

Ospemifene

Description:

Ospemifene is a selective estrogen receptor modulator (SERM) primarily used in the treatment of dyspareunia, a condition characterized by painful intercourse due to vaginal atrophy associated with menopause. As a non-steroidal compound, it exhibits tissue-selective estrogenic activity, meaning it can mimic estrogen in certain tissues while blocking its effects in others. Ospemifene is known for its ability to promote vaginal and vulvar health by enhancing the thickness and elasticity of vaginal tissue, thereby alleviating discomfort. The substance has a relatively low bioavailability and is metabolized in the liver, with its pharmacokinetics influenced by various factors, including age and liver function. Common side effects may include hot flashes, vaginal discharge, and potential risks associated with estrogen therapy, such as thromboembolic events. Ospemifene's unique mechanism of action and its targeted approach make it a significant option for managing menopausal symptoms, particularly in women who cannot or prefer not to use traditional hormone replacement therapies.

Formula: C₂₄H₂₃ClO₂

InChI: InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-

InChI key: InChIKey=LUMKNAVTFCDUIE-VHXPQNKSSA-N

SMILES: C(=C(/CCCl)\C1=CC=CC=C1)(\C2=CC=C(OCCO)C=C2)/C3=CC=CC=C3

Synonyms:

• 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol
• 2-[4-[4-Chloro-1,2-diphenyl-1(Z)-butenyl]phenoxy]ethanol
• 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethanol
• Ethanol, 2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-, (Z)-
• Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-
• Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-
• FC-1271a
• Fc 1271
• Osphena
• Senshio

Ospemifene

CAS: 128607-22-7

Formula: C₂₄H₂₃ClO₂

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 378.90

Ref: 3B-O0441

Ospemifene

CAS: 128607-22-7

Formula: C₂₄H₂₃ClO₂

Color and Shape: White To Off-White Solid

Molecular weight: 378.90

Ref: 4Z-O-046001

Ospemifene-d4

CAS: 128607-22-7

Formula: C₂₄H₁₉D₄ClO₂

Color and Shape: Off-White Solid

Molecular weight: 382.92

Ref: 4Z-O-046002

Ospemifene

CAS: 128607-22-7

Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.

Formula: C₂₄H₂₃ClO₂

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 378.89

Ref: TM-T6620

Ospemifene-d4

Controlled Product

CAS: 128607-22-7

Applications Ospemifene-d4 is the isotope labelled analog of Ospemifene (O703000). Ospemifene is used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rutanen, E., et al.: Menopause, 10, 433 (2003);

Formula: C₂₄D₄H₁₉ClO₂

Color and Shape: Neat

Molecular weight: 382.916

Ref: TR-O703002

Ospemifene

Controlled Product

CAS: 128607-22-7

Applications Ospemifene is used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rutanen, E., et al.: Menopause, 10, 433 (2003);

Formula: C₂₄H₂₃ClO₂

Color and Shape: White To Off-White

Molecular weight: 378.89

Ref: TR-O703000

Ospemifene

Controlled Product

CAS: 128607-22-7

2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol is a selective estrogen receptor modulator that has been shown to inhibit the growth of breast cancer cells in mice. It binds to the estrogen receptor (ER) and inhibits its transcriptional activity by competing with estradiol for binding. 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol can be used as a postmenopausal hormonal therapy in women who are at an increased risk for breast cancer. This drug has been shown to have genotoxic activity and may cause dyspareunia and carcinogenic potential.

Formula: C₂₄H₂₃ClO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 378.89 g/mol

Ref: 3D-FC57468

Ospemifene-13C2,d4

Controlled Product

CAS: 128607-22-7

Formula: C₂C₂₂D₄H₁₉ClO₂

Color and Shape: Neat

Molecular weight: 384.901

Ref: TR-O703004

Ospemifene-d4

Controlled Product

CAS: 128607-22-7

Applications Ospemifene-d4 is the isotope labelled analog of Ospemifene (O703000). Ospemifene is used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rutanen, E., et al.: Menopause, 10, 433 (2003);

Formula: C₂₄D₄H₁₉ClO₂

Color and Shape: Neat

Molecular weight: 382.916

Ref: TR-O703003

Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-

CAS: 128607-22-7

Formula: C₂₄H₂₃ClO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.8912

Ref: IN-DA000Y8C