CAS 128625-52-5

PyBOP

Description:

PyBOP, or benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, is a coupling reagent commonly used in peptide synthesis. It facilitates the formation of peptide bonds by activating carboxylic acids, making them more reactive towards amines. PyBOP is characterized by its high efficiency and mild reaction conditions, which help minimize side reactions and protect sensitive functional groups. It is typically used in solid-phase peptide synthesis and solution-phase reactions. The reagent is known for its stability and ease of handling, often being preferred over other coupling agents due to its ability to provide high yields of the desired peptide products. Additionally, PyBOP is soluble in common organic solvents, which enhances its versatility in various synthetic protocols. However, it is important to handle PyBOP with care, as it can be hazardous, and appropriate safety measures should be taken during its use. Overall, PyBOP is a valuable tool in the field of organic and medicinal chemistry, particularly in the synthesis of complex peptides.

Formula: C₁₈H₂₈N₆OP·F₆P

InChI: InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1

InChI key: InChIKey=VIAFLMPQBHAMLI-UHFFFAOYSA-N

SMILES: [P+](ON1C=2C(N=N1)=CC=CC2)(N3CCCC3)(N4CCCC4)N5CCCC5.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]

Synonyms:

• (1-Hydroxy-1H-benzotriazolato-O)tri-1-pyrrolidinylphosphorus(1+) hexafluorophosphate(1-)
• 1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate
• 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate
• 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
• Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
• Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
• Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
• Phosphorus(1+), [1-(hydroxy-κO)-1H-benzotriazolato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
• PyBOP
• Pyrrolidine, phosphorus complex

1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]

CAS: 128625-52-5

Formula: C₁₈H₂₈F₆N₆OP₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 520.40

Ref: 3B-B1774

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

CAS: 128625-52-5

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent. This Thermo Scientific C

Formula: C₁₈H₂₈N₆OP

Purity: 98%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 375.44

Ref: 02-B25251

1H-Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

Formula: C₁₈H₂₈F₆N₆OP₂

Purity: 98.0%

Color and Shape: Solid, Powder or Crystalline Powder or Solid or Chunks

Molecular weight: 520.401

Ref: 10-F009017

PyBOP

CAS: 128625-52-5

A trademark of Merck KGaA, Darmstadt, Germany PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.

Formula: C₁₈H₂₈N₆OP·PF₆

Color and Shape: White

Molecular weight: 520.4

Ref: 01-4031604

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

Formula: C₁₈H₂₈F₆N₆OP₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 520.3925

Ref: IN-DA000Y92

Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate

CAS: 128625-52-5

Formula: C₁₈H₂₈N₆OP·PF₆

Purity: ≥ 97.5%

Color and Shape: White to off-white or slightly yellow crystalline powder

Molecular weight: 520.40

Ref: 7W-GE4655

[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

CAS: 128625-52-5

[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

Formula: C₁₈H₂₈N₆OP·PF₆

Purity: ≥95%

Color and Shape: white crystalline solid

Molecular weight: 520.39g/mol

Ref: 54-PC1208

Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate

Controlled Product

CAS: 128625-52-5

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.

Formula: C₁₈H₂₈N₆OP·F₆P

Color and Shape: Neat

Molecular weight: 520.39

Ref: TR-B207500

PyBOP

CAS: 128625-52-5

PyBOP is an acyclic nucleoside phosphonate that is structurally similar to cyclic peptides and coumarin derivatives. It has been shown to be active against infectious diseases such as malaria and hepatitis C, as well as metabolic disorders such as obesity. PyBOP also has a number of physiological effects, including thermal expansion and immunomodulation. PyBOP binds to the 3'-hydroxyl group of RNA by hydrogen bonding interactions in vivo and inhibits rRNA synthesis, leading to the inhibition of protein synthesis. This drug also disrupts the disulfide bond between cysteine residues in proteins, which may lead to autoimmune diseases. PyBOP is water-soluble and highly soluble in organic solvents, but not soluble in water or polar solvents such as DMSO or acetone. br>br> The thermal expansion coefficient for PyBOP is about 10^6 K^-1mol^

Formula: C₁₈H₂₈N₆OP₂F₆

Purity: Min. 95%

Molecular weight: 520.39 g/mol

Ref: 3D-KPC-1068-PI

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

PyBOP is a phosphonium salt used as a coupling reagent for peptide synthesis. PyBOP is very efficient: high yields, low epimerisation and high conversion rates can be achieved. PyBOP generates an activated HOBt ester in situ, in the presence of a base such as triethylamine or Hünig’s base. PyBOP is the pyrrolidino derivative of the phosphonium coupling reagent BOP, which is equally efficient, but generates the extremely toxic and carcinogenic HMPA as a by-product in situ. PyBOP is generally preferred over BOP because it gives comparable performances but generates a less toxic by-product.

Formula: C₁₈H₂₈N₆OP·PF₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 520.39 g/mol

Ref: 3D-FP15550