CAS 1286770-55-5

N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide

Description:

N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide is a chemical compound characterized by its complex structure, which includes a thiadiazine ring, multiple fluorine substituents, and an amide functional group. This compound is notable for its potential pharmacological applications, particularly in the field of medicinal chemistry, where it may exhibit biological activity against specific targets. The presence of the fluorine atoms can enhance lipophilicity and metabolic stability, which are desirable properties in drug design. The thiadiazine moiety contributes to its unique reactivity and interaction with biological systems. Additionally, the compound's stereochemistry, indicated by the (5R) configuration, may influence its biological activity and binding affinity to target proteins. Overall, this substance represents a class of compounds that may be explored for therapeutic uses, although specific biological data and safety profiles would need to be evaluated through further research.

Formula: C₁₇H₁₇F₂N₅O₃S

InChI: InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1

InChI key: InChIKey=YHYKUSGACIYRML-KRWDZBQOSA-N

SMILES: C[C@@]1(C2=CC(NC(=O)C3=CC=C(F)C=N3)=CC=C2F)CS(=O)(=O)N(C)C(N)=N1

Synonyms:

• 2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-
• Verubecestat
• MK 8931
• N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide

2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-

CAS: 1286770-55-5

Formula: C₁₇H₁₇F₂N₅O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 409.4104

Ref: IN-DA000YAT

Verubecestat

CAS: 1286770-55-5

Verubecestat

Purity: ≥90%

Molecular weight: 409.41g/mol

Ref: 54-BUP12954

Verubecestat

CAS: 1286770-55-5

Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.

Formula: C₁₇H₁₇F₂N₅O₃S

Purity: 92.24% - 99.55%

Color and Shape: Solid

Molecular weight: 409.41

Ref: TM-T7011

Verubecestat

Controlled Product

CAS: 1286770-55-5

Applications Verubecestat is used in a β-site amyloid precursor protein cleaving enzyme I inhibitor of treatment of alzheimer’s disease.
References Scott, J. et al.: J. Med. Chem., 59, 10435 (2016);

Formula: C₁₇H₁₇F₂N₅O₃S

Color and Shape: Neat

Molecular weight: 409.41

Ref: TR-V128850

Verubecestat

CAS: 1286770-55-5

Verubecestat is an experimental drug that has been shown to reduce the production of amyloid-beta protein, one of the key proteins in Alzheimer's disease. Verubecestat acts by blocking the activity of beta-secretase 1 (BACE1), which is an enzyme that is involved in the production of amyloid-beta protein. The drug also inhibits acetylcholine release and neuronal death, thereby reducing neuronal dysfunction. Verubecestat has been shown to be well tolerated with no adverse effects seen in clinical trials. It is being studied for use as a symptomatic treatment for patients with mild to moderate Alzheimer's disease. There are few side effects associated with this drug and it does not appear to cause any significant changes in laboratory values or blood counts.

Formula: C₁₇H₁₇F₂N₅O₃S

Purity: Min. 95%

Molecular weight: 409.41 g/mol

Ref: 3D-LBC77055