CAS 1287241-26-2

PAC-1-d8

Description:

PAC-1-d8, identified by its CAS number 1287241-26-2, is a deuterated derivative of PAC-1, a small molecule known for its role in modulating apoptosis in cancer cells. The deuteration refers to the substitution of hydrogen atoms with deuterium, which can enhance the stability and metabolic properties of the compound. PAC-1 itself is recognized for its ability to activate procaspase-3, thereby promoting programmed cell death, making it a subject of interest in cancer research. The deuterated version, PAC-1-d8, is often utilized in studies involving pharmacokinetics and metabolic pathways, as the presence of deuterium can aid in distinguishing the compound from its non-deuterated counterparts during analytical assessments. This modification may also influence the compound's solubility, bioavailability, and overall efficacy in therapeutic applications. As with many research chemicals, the specific characteristics such as solubility, stability, and reactivity can vary based on the formulation and conditions under which it is studied.

Formula: C₂₃H₂₈N₄O₂

Synonyms:

• YQNRVGJCPCNMKT-SRNXAORYSA-N
• PAC-1-d8
• [2H8]-PAC-1

PAC-1-d8

Controlled Product

CAS: 1287241-26-2

Applications Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),

Formula: C₂₃H₂₀D₈N₄O₂

Color and Shape: Neat

Molecular weight: 400.54

Ref: TR-P132002

PAC-1-d8

CAS: 1287241-26-2

PAC-1-d8 is a monoclonal antibody that binds to the protein phosphatase 1 (PP1) and inhibits its activity. PAC-1-d8 is used in cancer research to study the effects of PP1 on tumor cells. It has been shown to inhibit tumor growth in breast cancer, melanoma, lymphoma, and solid tumors. PAC-1-d8 is administered intravenously or intraperitoneally and it has also been shown to have few side effects in mice with breast cancer.

Formula: C₂₃H₂₀D₈N₄O₂

Purity: Min. 95%

Molecular weight: 400.54 g/mol

Ref: 3D-MBC24126