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CAS 128794-94-5

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Mycophenolate mofetil

Description:
Mycophenolate mofetil (MMF) is an immunosuppressive agent primarily used in organ transplantation and autoimmune diseases. It is a prodrug that is converted in the body to mycophenolic acid, which inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH). This inhibition selectively affects lymphocytes, thereby suppressing the proliferation of T and B cells and reducing the immune response. MMF is characterized by its relatively high solubility in organic solvents and low solubility in water, which influences its formulation and administration. The substance is typically administered orally and is known for its pharmacokinetic properties, including a peak plasma concentration reached within a few hours after ingestion. Common side effects include gastrointestinal disturbances, increased risk of infections, and potential hematological effects such as leukopenia. Due to its immunosuppressive nature, careful monitoring is essential during treatment to mitigate risks associated with infections and organ rejection. Overall, mycophenolate mofetil plays a crucial role in managing conditions requiring immune modulation.
Formula:C23H31NO7
InChI:InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
InChI key:InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N
SMILES:CC1=C2C(=C(O)C(C/C=C(/CCC(OCCN3CCOCC3)=O)\C)=C1OC)C(=O)OC2
Synonyms:
  • 2-(Morpholin-4-Yl)Ethyl 6-(4-Hydroxy-6-Methoxy-7-Methyl-3-Oxo-1,3-Dihydro-2-Benzofuran-5-Yl)-4-Methylhex-4-Enoate
  • 2-Morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate
  • 2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
  • 4-Hexenoic Acid,6-(1,3-Dihydro-4-Hydroxy-6-Methoxy-7-Methyl-3-Oxo-5-Isobenzofuranyl)-4-Methyl-,2-(4-Morpholinyl)Ethyl Ester
  • 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)-
  • 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-
  • 6-[(7-Hydroxy-5-Methoxy-4-Methyl-1-Oxo-3H-Isobenzofuran-6-Yl)]-4-Methyl-Hex-4-Enoic Acid 2-Morpholinoethyl Ester
  • Linfonex
  • MMF
  • Macophenolate Mofetil
  • See more synonyms
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