CAS 128837-83-2

N-(3-fluoropropyl)-N-norbuprenorphine

Description:

N-(3-fluoropropyl)-N-norbuprenorphine is a synthetic derivative of buprenorphine, which is an opioid used primarily for pain management and as a treatment for opioid addiction. This compound features a fluoropropyl group, which enhances its pharmacological properties and may influence its receptor binding affinity and selectivity. The presence of the fluorine atom can also affect the lipophilicity and metabolic stability of the molecule. As a modified version of norbuprenorphine, it retains the core structure of the parent compound while potentially exhibiting altered efficacy and safety profiles. The compound is likely to interact with opioid receptors, particularly the mu-opioid receptor, but its specific activity and therapeutic potential would depend on detailed pharmacological studies. Additionally, like other opioids, it may carry risks of dependence and side effects, necessitating careful consideration in clinical applications. Overall, N-(3-fluoropropyl)-N-norbuprenorphine represents a notable example of how chemical modifications can lead to new therapeutic agents in the field of pain management and addiction treatment.

Formula: C₂₈H₄₀FNO₄

InChI: InChI=1/C28H40FNO4/c1-24(2,3)25(4,32)19-16-26-9-10-28(19,33-5)23-27(26)11-14-30(13-6-12-29)20(26)15-17-7-8-18(31)22(34-23)21(17)27/h7-8,19-20,23,31-32H,6,9-16H2,1-5H3

SMILES: CC(C)(C)C(C)(C1CC23CCC1(C1C43CCN(CCCF)C2Cc2ccc(c(c42)O1)O)OC)O

Synonyms:

• 3-Fpnbp
• 17-(3-Fluoropropyl)-18-(2-Hydroxy-3,3-Dimethylbutan-2-Yl)-6-Methoxy-18,19-Dihydro-4,5-Epoxy-6,14-Ethenomorphinan-3-Ol
• N-(3-Fluoropropyl)-N-norbuprenorphine