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CAS 128858-43-5

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Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite

Description:
Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite is a chemical compound characterized by its phosphoramidite structure, which is commonly used in the field of organic synthesis, particularly in the synthesis of oligonucleotides. This compound features a phosphorous atom bonded to two isopropyl groups and a p-chlorobenzyl moiety, contributing to its reactivity and stability. The presence of the p-chlorobenzyl group enhances its lipophilicity, making it suitable for various applications in medicinal chemistry and biochemistry. As a phosphoramidite, it serves as a key intermediate in the phosphorylation of nucleosides, facilitating the formation of phosphodiester bonds in nucleic acid synthesis. The compound is typically handled under anhydrous conditions due to its sensitivity to moisture, which can lead to hydrolysis. Its unique structural features and reactivity profile make it a valuable reagent in synthetic organic chemistry, particularly in the development of nucleic acid-based therapeutics and diagnostics. Safety precautions should be observed when handling this compound, as it may pose health risks if ingested or inhaled.
Formula:C20H26Cl2NO2P
InChI:InChI=1/C20H26Cl2NO2P/c1-15(2)23(16(3)4)26(24-13-17-5-9-19(21)10-6-17)25-14-18-7-11-20(22)12-8-18/h5-12,15-16H,13-14H2,1-4H3
SMILES:CC(C)N(C(C)C)P(OCc1ccc(cc1)Cl)OCc1ccc(cc1)Cl
Synonyms:
  • Bis(4-Chlorobenzyl) Bis(1-Methylethyl)Amidophosphite
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Found 2 products.
  • Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis[(4-chlorophenyl)methyl] ester
    Indagoo
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    Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis[(4-chlorophenyl)methyl] ester

    CAS:
    Formula:C20H26Cl2NO2P
    Color and Shape:Solid
    Molecular weight:414.3057

    Ref: IN-DA000YFR

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  • Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite
    TRC
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    Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite

    Controlled Product
    CAS:
    <p>Stability Moisture Sensitive<br>Applications A versatile phosphitylating agent for the phosphorylation of hydroxy amino acids and the preparation of protected phosphopeptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liskamp, R.M.J., et al.: Recl. Trav. Chim. Pays-Bas, 109, 27 (1990)<br></p>
    Formula:C20H26Cl2NO2P
    Color and Shape:Neat
    Molecular weight:414.31

    Ref: TR-D432500

    1g
    204.00€