CAS 1289023-67-1

Rimegepant

Description:

Rimegepant is a small molecule medication primarily used for the acute treatment of migraine in adults. It functions as a selective antagonist of the calcitonin gene-related peptide (CGRP) receptor, which plays a significant role in the pathophysiology of migraine. By blocking the action of CGRP, Rimegepant helps to alleviate migraine symptoms. The substance is characterized by its oral bioavailability, allowing for convenient administration. It has a relatively short half-life, which necessitates dosing considerations based on individual patient needs. Rimegepant is generally well-tolerated, with a side effect profile that may include nausea and somnolence, although serious adverse effects are rare. Its development represents a shift towards targeted therapies in migraine management, focusing on specific pathways involved in migraine attacks rather than traditional analgesics. As a novel therapeutic option, Rimegepant offers an alternative for patients who may not respond to or tolerate conventional treatments.

Formula: C₂₈H₂₈F₂N₆O₃

InChI: InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1

InChI key: InChIKey=KRNAOFGYEFKHPB-ANJVHQHFSA-N

SMILES: O=C1N(C=2C(N1)=NC=CC2)C3CCN(C(O[C@H]4C=5C([C@@H](N)[C@@H](CC4)C6=C(F)C(F)=CC=C6)=CC=CN5)=O)CC3

Synonyms:

• 4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylic acid (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester
• BMS 927711
• 1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester
• Nurtec ODT
• Rimegepant
• Nurtec

Rimegepant-d4

CAS: 1289023-67-1

Formula: C₂₈H₂₄D₄F₂N₆O₃

Molecular weight: 538.59

Ref: 4Z-R-152004

Rimegepant

CAS: 1289023-67-1

Rimegepant

Purity: ≥98%

Molecular weight: 534.56g/mol

Ref: 54-BUP01366

Rimegepant

CAS: 1289023-67-1

Formula: C₂₈H₂₈F₂N₆O₃

Molecular weight: 534.57

Ref: 4Z-R-152001

Rimegepant

CAS: 1289023-67-1

View and buy Rimegepant from TargetMol.BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.Cited in 1 publications.

Formula: C₂₈H₂₈F₂N₆O₃

Purity: 99.1% - 99.99%

Color and Shape: Solid

Molecular weight: 534.56

Ref: TM-T4610