CAS 129-49-7

Methysergide maleate

Description:

Methysergide maleate is a synthetic compound primarily known for its use in the treatment of migraine headaches and cluster headaches. It is a derivative of lysergic acid and acts as a serotonin receptor antagonist, particularly at the 5-HT2 receptor sites. The substance appears as a white to off-white crystalline powder and is typically administered in the form of tablets. Methysergide maleate is characterized by its relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. It has a moderate half-life, allowing for once or twice daily dosing in clinical settings. However, prolonged use can lead to side effects, including retroperitoneal fibrosis and pulmonary hypertension, necessitating careful monitoring of patients. Due to these potential adverse effects, its use has become less common, and it is often considered when other treatments have failed. Methysergide maleate is classified under the category of ergot alkaloids, which are known for their vasoconstrictive properties.

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

InChI: InChI=1/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

SMILES: CN1C2=C3C(C=4[C@@](CC3=C1)(N(C)C[C@H](C(N[C@@H](CC)CO)=O)C4)[H])=CC=C2.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (+)-N-[(1-Hydroxymethyl)propyl]-1-methyl-<span class="text-smallcaps">D</span>-lysergamide bimaleate
• (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
• (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
• 1-Methyl-<span class="text-smallcaps">D</span>-lysergic acid butanolamide bimaleate
• Deseril-retard
• Desernil
• Desernil bimaleate
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt)
• Ergoline-8β-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, maleate (1:1) (salt)
• Lysergamide, N-[1-(hydroxymethyl)propyl]-1-methyl-, maleate
• Methysergide Hydrogen Maleate
• Methysergide bimaleate
• NSC 186061

Methysergide Maleate

CAS: 129-49-7

Alkaloids of rye ergot and their derivatives; salts the

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Color and Shape: Powder

Molecular weight: 469.22129

Ref: 45-1440003

Methysergide maleate salt

CAS: 129-49-7

Formula: C₂₅H₃₁N₃O₆

Purity: ≥ 99.0% (anhydrous)

Color and Shape: White to off-white crystalline powder

Molecular weight: 469.53

Ref: 7W-GP2886

Methysergide Maleate

Controlled Product

CAS: 129-49-7

Stability Hygroscopic
Applications Methysergide Maleate acts as a serotonin antagonist with potential application antidepression medication. It is a 5-HT antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masalov, I. et al.: J. Evol. Biochem. Phys., 48, 523 (2012); Fletcher, P. et al.: Psychopharm., 96, 236 (1988);

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 469.53

Ref: TR-M329350

Methysergide maleate monohydrate

Controlled Product

CAS: 129-49-7

Methylergide maleate monohydrate is a high-quality reagent that is useful as an intermediate for the synthesis of complex compounds. It is also a fine chemical that can be used in research and development. Methylergide maleate monohydrate has CAS No. 129-49-7, and it can be used to produce speciality chemicals or reaction components. It has a wide range of applications, such as being a versatile building block in organic synthesis and being a reaction component for the production of pharmaceuticals or agrochemicals.

Formula: C₂₅H₃₃N₃O₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 487.55 g/mol

Ref: 3D-FM39378

Methysergide maleate

Controlled Product

CAS: 129-49-7

Methysergide is a drug that has been used in the treatment of chronic schizophrenia and other neurological disorders. It is an antagonist of glutamate, which inhibits the release of 5-HT (serotonin) and thereby reduces the concentration of this neurotransmitter in the brain. Methysergide has also been shown to inhibit the production of carcinoid syndrome and gamma-aminobutyric acid (GABA). Methysergide is related to estradiol benzoate, which is used to treat autoimmune diseases such as systemic lupus erythematosus (SLE). Symptoms may include fever, joint pain, photosensitivity, skin rash, muscle pain, and weight loss. The pharmacological treatment for these symptoms includes methotrexate or corticosteroids.

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Purity: Min. 95%

Molecular weight: 469.53 g/mol

Ref: 3D-FM75152

Methysergide maleate

CAS: 129-49-7

Methysergide prevents migraines/cluster headaches; treats serotonin syndrome, carcinoid-induced diarrhea; risk of fibrosis limits use.

Formula: C₂₅H₃₁N₃O₆

Purity: 98%

Color and Shape: White To Off-White

Molecular weight: 469.54

Ref: TM-T21423

Methysergide maleate

CAS: 129-49-7

Methysergide maleate

Formula: C₂₁H₂₇N₃O₂

Purity: 72.6%

Color and Shape: Off White Solid

Molecular weight: 353.21033

Ref: 47-409