CAS 129-74-8

Buclizine hydrochloride

Description:

Buclizine hydrochloride is an antihistamine primarily used to alleviate symptoms of motion sickness and to treat allergies. It belongs to the piperazine class of compounds and exhibits sedative properties, making it effective in reducing nausea and vomiting associated with travel. The substance is characterized by its ability to block H1 histamine receptors, which helps in mitigating allergic reactions. Buclizine hydrochloride is typically administered orally and is known for its relatively long duration of action. In terms of physical properties, it is a white to off-white crystalline powder that is soluble in water and alcohol. The compound has a molecular formula that reflects its complex structure, contributing to its pharmacological effects. While generally well-tolerated, it may cause side effects such as drowsiness, dry mouth, and dizziness. As with any medication, it is important to use buclizine hydrochloride under medical supervision to ensure safety and efficacy, particularly in individuals with pre-existing health conditions or those taking other medications.

Formula: C₂₈H₃₃ClN₂·2ClH

InChI: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

InChI key: InChIKey=SDBHDSZKNVDKNU-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=C(Cl)C=C3)C4=CC=CC=C4.Cl

Synonyms:

• 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
• 1-(4-Tert-Butylbenzyl)-4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazine Dihydrochloride
• 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine hydrochloride
• 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride
• 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride
• Aphilan R
• Bucladin S
• Buclina
• Buclizine HCl
• Buclizine Hydrochloride
• Buclodin
• Histabutyzine hydrochloride
• Longifene
• NSC 25141
• Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)
• Softran
• Ucb 4445
• Vibazine

Buclizine Hydrochloride

CAS: 129-74-8

Color and Shape: Neat

Ref: 61-FOR0475.00

Buclizine hydrochloride impurity standard

CAS: 119-56-2, 129-74-8, 134-85-0, 303-26-4

Buclizine hydrochloride impurity standard

Color and Shape: White

Ref: 47-440

Buclizine dihydrochloride

CAS: 129-74-8

Formula: C₂₈H₃₅Cl₃N₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 505.9499

Ref: IN-DA007NAA

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine dihydrochloride

Purity: ≥98%

Molecular weight: 505.95g/mol

Ref: 54-BUP14697

Buclizine DiHCl

CAS: 129-74-8

Formula: C₂₈H₃₃ClN₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 433.04 2*36.46

Ref: 4Z-B-211

Buclizine Dihydrochloride

CAS: 129-74-8

Buclizine Dihydrochloride

Purity: 99%

Molecular weight: 505.95g/mol

Ref: 54-OR1028300

Buclizine Hydrochloride

Controlled Product

CAS: 129-74-8

Formula: C₂₈H₃₃ClN₂ClH

Color and Shape: Neat

Molecular weight: 505.95

Ref: 86-MM0475.00

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and

Formula: C₂₈H₃₃ClN₂·2HCl

Purity: 98.05%

Color and Shape: Off-White Powder

Molecular weight: 505.95

Ref: TM-T6426

Buclizine-d8 DiHCl

CAS: 129-74-8

Formula: C₂₈H₂₅D₈ClN₂·2HCl

Molecular weight: 441.14 2 36.46

Ref: 4Z-B-212

Buclizine, Dihydrochloride

Controlled Product

CAS: 129-74-8

Applications Used as an antiemetic.
References Jorgensen, P.B., et al.: Curr. Ther. Res., 16, 1276 (1974), Adam, E.I.: J. Int. Med. Res., 15, 71 (1987)

Formula: C₂₈H₃₃ClN₂·2ClH

Color and Shape: White

Molecular weight: 505.95

Ref: TR-B689450

Buclizine Dihydrochloride

CAS: 129-74-8

Formula: C₂₈H₃₃ClN₂(HCl)

Molecular weight: 433.0 : 2(36.5)

Ref: ST-EA-CP-B30003

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine is a tricyclic antidepressant that inhibits the activity of dopamine receptors. It can be used to treat nausea and vomiting, which are symptoms of many chronic diseases, including cancer. Buclizine also has anti-infectious effects and can inhibit the growth of bacteria by preventing their ability to synthesize DNA. This drug is used as an antimicrobial agent for the treatment of infectious diseases such as syphilis and leprosy. The hypoglycemic effect of buclizine may be due to its ability to inhibit insulin release or to decrease the production of glucose by liver cells.

Formula: C₂₈H₃₅Cl₃N₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 505.95 g/mol

Ref: 3D-FB146989

Buclizine (piperazine-d8) Dihydrochloride

Controlled Product

CAS: 129-74-8

Applications Buclizine (piperazine-d8) Dihydrochloride used as an antiemetic. It is the labelled version of B689450.
References Jorgensen, P.B., et al.: Curr. Ther. Res., 16, 1276 (1974); Adam, E.I.: J. Int. Med. Res., 15, 71 (1987)

Formula: C₂₈H₂₇D₈Cl₃N₂

Color and Shape: Neat

Molecular weight: 441.077

Ref: TR-B689452