CAS 129-74-8: Buclizine hydrochloride

Description: Buclizine hydrochloride is an antihistamine primarily used to alleviate symptoms of motion sickness and to treat allergies. It belongs to the piperazine class of compounds and exhibits sedative properties, making it effective in reducing nausea and vomiting associated with travel. The substance is characterized by its ability to block H1 histamine receptors, which helps in mitigating allergic reactions. Buclizine hydrochloride is typically administered orally and is known for its relatively long duration of action. In terms of physical properties, it is a white to off-white crystalline powder that is soluble in water and alcohol. The compound has a molecular formula that reflects its complex structure, contributing to its pharmacological effects. While generally well-tolerated, it may cause side effects such as drowsiness, dry mouth, and dizziness. As with any medication, it is important to use buclizine hydrochloride under medical supervision to ensure safety and efficacy, particularly in individuals with pre-existing health conditions or those taking other medications.

Formula: C₂₈H₃₃ClN₂·2ClH

InChI: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

InChI key: InChIKey=SDBHDSZKNVDKNU-UHFFFAOYSA-N

SMILES: Cl.ClC1=CC=C(C=C1)C(C=2C=CC=CC2)N3CCN(CC4=CC=C(C=C4)C(C)(C)C)CC3

Synonyms:

• 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
• 1-(4-Tert-Butylbenzyl)-4-[(4-Chlorophenyl)(Phenyl)Methyl]Piperazine Dihydrochloride
• 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine hydrochloride
• 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride
• 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride
• Aphilan R
• Bucladin S
• Buclina
• Buclizine HCl
• Buclizine Hydrochloride
• Buclodin
• Histabutyzine hydrochloride
• Longifene
• NSC 25141
• Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)
• Softran
• Ucb 4445
• Vibazine
• Vibazine Hydrochloride

Buclizine hydrochloride impurity standard

CAS: 119-56-2 129-74-8134-85-0 303-26-4

• Color and Shape: White

Buclizine Dihydrochloride

CAS: 129-74-8

• Formula: C₂₈H₃₅Cl₃N₂
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 505.9499

Buclizine DiHCl

CAS: 129-74-8

• Formula: C₂₈H₃₃ClN₂·2HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 433.04 2*36.46

Buclizine dihydrochloride

CAS: 129-74-8

• Purity: ≥98%
• Molecular weight: 505.95g/mol

Buclizine Dihydrochloride

CAS: 129-74-8

• Purity: 99%
• Molecular weight: 505.95g/mol

Buclizine Hydrochloride

CAS: 129-74-8

• Formula: C₂₈H₃₃ClN₂ClH
• Color and Shape: Neat
• Molecular weight: 505.95

Buclizine dihydrochloride

CAS: 129-74-8

Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor …

• Formula: C₂₈H₃₃ClN₂·2HCl
• Purity: 98.05%
• Color and Shape: Off-White Powder
• Molecular weight: 505.95

Buclizine-d8 DiHCl

CAS: 129-74-8

• Formula: C₂₈H₂₅D₈ClN₂·2HCl
• Molecular weight: 441.14 2 36.46

Buclizine, Dihydrochloride

CAS: 129-74-8

Applications Used as an antiemetic. References Jorgensen, P.B., et al.: Curr. Ther. Res., 16, 1276 …

• Formula: C₂₈H₃₃ClN₂ClH
• Color and Shape: White
• Molecular weight: 505.95

Buclizine dihydrochloride

CAS: 129-74-8

Please enquire for more information about Buclizine dihydrochloride including the price, delivery time and more …

• Formula: C₂₈H₃₅Cl₃N₂
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 505.95 g/mol

Buclizine (piperazine-d8) Dihydrochloride

CAS: 129-74-8

Applications Buclizine (piperazine-d8) Dihydrochloride used as an antiemetic. It is the labelled version of B689450. …

• Formula: C₂₈H₂₇D₈Cl₃N₂
• Color and Shape: Neat
• Molecular weight: 441.077