CAS 1290543-63-3

PF-3084014

Description:

PF-3084014, with the CAS number 1290543-63-3, is a chemical compound that has garnered attention in pharmaceutical research, particularly in the context of oncology. It is classified as a small molecule inhibitor, specifically targeting certain pathways involved in cancer cell proliferation and survival. The compound is designed to interfere with specific protein interactions or enzymatic activities that are crucial for tumor growth. Its mechanism of action typically involves modulation of signaling pathways, which can lead to apoptosis in cancer cells. PF-3084014 has been evaluated in preclinical studies for its efficacy and safety profile, showing promise in various cancer models. As with many investigational drugs, its characteristics, including solubility, stability, and pharmacokinetics, are critical for its development and potential therapeutic applications. Ongoing research aims to further elucidate its biological activity and optimize its use in clinical settings.

Formula: C₂₇H₄₁F₂N₅O

Synonyms:

• PF03084014;PF 03084014;PF-03084014
• CS-2699
• PF-03084014 (PF-3084014)
• Nirogacestat(PF-03084014,PF-3084014)
• (S)-2-((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide Molecular Weight: 489.64
• Nirogacestat
• PF-03084014 (Nirogacestat)
• (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
• Pentanamide, 2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-, (2S)-
• PF-3084014

PF-3084014

CAS: 1290543-63-3

Formula: C₂₇H₄₁F₂N₅O

Purity: %

Color and Shape: Solid

Molecular weight: 489.6441

Ref: IN-DA009CE4

Nirogacestat

CAS: 1290543-63-3

Nirogacestat

Purity: ≥95%

Molecular weight: 489.64g/mol

Ref: 54-BUP03122

Nirogacestat

CAS: 1290543-63-3

Formula: C₂₇H₄₁F₂N₅O

Molecular weight: 489.66

Ref: 4Z-N-180001

Nirogacestat

CAS: 1290543-63-3

Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).

Formula: C₂₇H₄₁F₂N₅O

Purity: 97.98% - 99.63%

Color and Shape: Solid

Molecular weight: 489.64

Ref: TM-T6935

Nirogacestat

CAS: 1290543-63-3

Nirogacestat is a secretase inhibitor that binds to the catalytic site of the enzyme, thereby preventing the cleavage of amyloid beta-protein into its toxic fragments. It has been shown to be effective in treating infectious diseases such as HIV infection, and also has anti-inflammatory properties. Nirogacestat also exhibits antitumor response in solid tumor models. Nirogacestat inhibits endothelial cell growth by blocking the release of angiogenic factors such as epidermal growth factor and VEGF. This drug also has an effect on body mass index and may have antiangiogenic properties.

Formula: C₂₇H₄₁F₂N₅O

Purity: Min. 95%

Molecular weight: 489.64 g/mol

Ref: 3D-QBC54363