CAS 1290606-20-0
:Rapamycin, 12-demethyl-12-ethyl-
Description:
Rapamycin, 12-demethyl-12-ethyl- is a derivative of rapamycin, a macrolide compound originally discovered in the soil bacterium *Streptomyces hygroscopicus*. This substance is known for its immunosuppressive and anti-proliferative properties, making it significant in medical applications, particularly in organ transplantation and cancer therapy. The chemical structure features a large lactone ring and several functional groups that contribute to its biological activity. It acts primarily by inhibiting the mammalian target of rapamycin (mTOR), a key regulator of cell growth and metabolism. The modification of the rapamycin structure, such as the removal of a methyl group and the addition of an ethyl group, can influence its pharmacological properties, including potency and solubility. As with other rapamycin analogs, this compound may exhibit varying degrees of efficacy and side effects, which are important considerations in therapeutic contexts. Overall, the unique characteristics of 12-demethyl-12-ethyl-rapamycin make it a subject of interest in pharmaceutical research and development.
Formula:C52H81NO13
Synonyms:- 12-Ethyl Rapamycin
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- Rapamycin, 12-demethyl-12-ethyl-
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