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CAS 129121-73-9

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ALPHA-CGRP (8-37) (RAT)

Description:
Alpha-CGRP (8-37) is a peptide that serves as a selective antagonist of the calcitonin gene-related peptide (CGRP) receptor. It is derived from the endogenous CGRP molecule, with specific modifications that enhance its antagonistic properties. This peptide is primarily studied in the context of neurobiology and pain research, particularly for its role in migraine pathophysiology. Alpha-CGRP (8-37) has been shown to inhibit the effects of CGRP, which is involved in vasodilation and the transmission of pain signals. The substance is characterized by its ability to bind to CGRP receptors, thereby blocking the physiological effects mediated by CGRP. Its structure includes a sequence of amino acids that contribute to its receptor-binding affinity and specificity. Research involving Alpha-CGRP (8-37) often focuses on its potential therapeutic applications in treating migraine and other conditions associated with CGRP signaling. As a synthetic peptide, it is typically used in laboratory settings for experimental purposes, and its safety and efficacy are evaluated in preclinical studies.
Formula:C138H224N42O41
Synonyms:
  • Cgrp 8-37 (Rat)
  • H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-Nh2
  • Calcitonin Gene Related Peptide (8-37) Rat
  • Alpha-Calcitonin Gene-Related Peptide (8-37) (Rat)
  • Vthrlagllsrsggvvkdnfvptnvgseaf-Nh2
  • Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-Nh2
  • α-CGRP (8-37) (mouse, rat)|Calcitonin Gene Related Peptide (8-37),rat
  • ALPHA-CGRP (8-37) (RAT)
  • ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
  • Alpha-CGRP (8-37) (mouse, rat)
  • See more synonyms
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Found 4 products.
  • α-CGRP (8-37) (mouse, rat)
    Bachem
    + Info

    α-CGRP (8-37) (mouse, rat)

    CAS:
    α-CGRP (8-37), a competitive CGRP1 receptor antagonist, exhibited hypothermic and antinociceptive effects. CGRP-I (8-37) antagonized the effects of amylin and amylin (1-8) on osteoblasts but was substantially less potent in this regard than amylin (8-37). Furthermore, it inhibited the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.
    Formula:C138H224N42O41
    Purity:95.7%
    Color and Shape:White Lyophilisate
    Molecular weight:3127.56

    Ref: 01-4034544

    1mg
    375.00€
    5mg
    1,421.00€
  • α-CGRP (8-37) (mouse, rat) trifluoroacetate salt
    Indagoo
    + Info

    α-CGRP (8-37) (mouse, rat) trifluoroacetate salt

    CAS:
    Formula:C138H224N42O41
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3127.5120

    Ref: IN-DA01EAP4

    5mg
    175.00€
    10mg
    305.00€
  • CGRP 8-37 (rat)
    Targetmol
    + Info

    CGRP 8-37 (rat)

    CAS:
    CGRP 8-37 (rat) is a CGRP receptor antagonist, a CGRP fragment with potential anti-injury effects that induces arterial relaxation.
    Formula:C138H224N42O41
    Purity:99.28%
    Color and Shape:Solid
    Molecular weight:3127.51

    Ref: TM-TP1323

  • α-CGRP (8-37) (mouse, rat) trifluoroacetate salt
    Biosynth
    + Info

    α-CGRP (8-37) (mouse, rat) trifluoroacetate salt

    CAS:
    Trifluoroacetate salt
    Formula:C138H224N42O41
    Purity:Min. 95%
    Molecular weight:3,127.51 g/mol

    Ref: 3D-FC109404

    2mg
    863.00€
    5mg
    949.00€
    10mg
    1,432.00€
    25mg
    2,788.00€