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CAS 129129-65-3

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U-conotoxin giiia

Description:
U-conotoxin GIIIA is a peptide toxin derived from the venom of the marine cone snail species Conus geographus. This compound is classified as a neurotoxin and is known for its ability to selectively block certain types of ion channels, particularly voltage-gated sodium channels. Its mechanism of action involves binding to these channels, which disrupts the normal flow of sodium ions across cell membranes, leading to paralysis in prey. U-conotoxin GIIIA exhibits high specificity and potency, making it a valuable tool in neurobiology research for studying ion channel function and potential therapeutic applications. The structure of this toxin typically consists of a small, compact arrangement of amino acids, often stabilized by disulfide bonds, which contributes to its stability and biological activity. Due to its unique properties, U-conotoxin GIIIA has garnered interest in drug development, particularly for pain management and neurological disorders. However, its use is primarily limited to research settings due to its toxic nature.
Formula:C100H170N38O32S6
Synonyms:
  • u-Conotoxin GIIIA, Conus geographus
  • H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Hyp-Gln-Arg-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/ Cys10 and Cys21)
  • .Mu.-Conotoxin G Iiia
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Found 2 products.
  • µ-Conotoxin GIIIA
    Bachem
    + Info

    µ-Conotoxin GIIIA

    CAS:
    µ-Conotoxin GIIIA from the Conus geographus L. venom blocks with very high selectivity the muscle subtype of sodium channels.
    Formula:C100H170N38O32S6
    Purity:93.6%
    Color and Shape:White Powder
    Molecular weight:2609.08

    Ref: 01-4030525

    1mg
    1,200.00€
    0.5mg
    729.00€
  • µ-Conotoxin GIIIA
    Biosynth
    + Info

    µ-Conotoxin GIIIA

    Controlled Product
    CAS:
    Conotoxins are peptides that can bind to specific receptors on the surface of cells. Their function is to regulate ion channels and thus affect cellular physiology. Conotoxin GIIIA is a disulfide-bonded peptide with a molecular weight of 5808 Da. It has been shown to inhibit Na+ channel activity in human serum, and may have diagnostic and therapeutic applications for diseases such as epilepsy. The amino acid sequence of conotoxin GIIIA is Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys (NH2)
    Formula:C100H170N38O32S6
    Purity:Min. 95%
    Molecular weight:2,609.05 g/mol

    Ref: 3D-FC108760

    1mg
    1,952.00€
    500µg
    1,083.00€