CAS 129133-27-3

(D-PHE12,NLE21,38)-CRF (12-41) (HUMAN, RAT)

Description:

The chemical substance known as (D-PHE12,NLE21,38)-CRF (12-41) is a synthetic analog of corticotropin-releasing factor (CRF), which is a peptide involved in the stress response in both humans and rats. This compound is characterized by specific amino acid substitutions, notably the incorporation of D-phenylalanine at position 12 and norleucine at position 21, which enhance its biological activity and stability compared to the natural form of CRF. The peptide consists of a sequence of 30 amino acids, and its structure allows it to interact with CRF receptors, playing a crucial role in regulating the hypothalamic-pituitary-adrenal (HPA) axis. The CAS number 129133-27-3 uniquely identifies this compound in chemical databases, facilitating research and application in pharmacology and biochemistry. Its potential therapeutic implications include the treatment of stress-related disorders and anxiety, making it a subject of interest in neuropharmacology. Overall, this synthetic peptide exemplifies the modifications made to naturally occurring peptides to enhance their pharmacological properties.

Formula: C₁₅₈H₂₆₅N₄₉O₄₃

Synonyms:

• (D-Phe12,Nle21,38)-Corticotropin-Releasing Factor (12-41) (Human, Rat)
• (Dphe12,Nle21'38)-Corticotropin Releasing Factor (12-41), Human, Rat
• (Dphe12,Nle21'38)-Crf (12-41), Human, Rat
• H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-Nh2
• corticotropin-releasing hormone(12-41), Phe(12)-Nle(21,38)-alpha-Me-Leu(37)-

(D-Phe12, Nle 21·38)-CRF (12-41) (human, rat) trifluoroacetate salt

CAS: 129133-27-3

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Formula: C₁₅₈H₂₆₅N₄₉O₄₃

Purity: Min. 95%

Molecular weight: 3,539.1 g/mol

Ref: 3D-FP109506