CAS 129203-60-7: iberiotoxin from buthus tamulus

Description: Iberiotoxin, derived from the venom of the Indian red scorpion (Buthus tamulus), is a potent neurotoxin known for its selective inhibition of certain potassium channels, particularly the voltage-gated potassium channels (Kv) in excitable tissues. This characteristic makes it a valuable tool in neuropharmacology for studying ion channel function and the physiological roles of potassium channels in various cellular processes. Iberiotoxin exhibits a high affinity for the Kv1.3 channel, which is implicated in immune responses and neuronal excitability. The toxin's structure is characterized by a polypeptide chain that folds into a specific three-dimensional conformation, allowing it to interact effectively with its target channels. Its mechanism of action involves binding to the channel and preventing potassium ion flow, which can lead to prolonged depolarization of neurons and muscle cells. Due to its potent effects, iberiotoxin is also of interest in research related to pain, inflammation, and potential therapeutic applications, although its use is primarily confined to laboratory settings due to its toxicity.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

InChI: InChI=1/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)

Synonyms:

• Iberiotoxin, Buthus tamulus
• Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/ Cys17 and Cys35)
• Iberiotoxin

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin (IbTx), from the venom of the scorpion Buthus tamulus, shows 68% sequence homology with …

• Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
• Purity: > 95%
• Color and Shape: Whitish Powder
• Molecular weight: 4230.91

L-Glutamine, 5-oxo-L-prolyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-cysteinyl-L-seryl-L-valyl-L-seryl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-tryptophyl-L-seryl-L-valyl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-leucyl-L-phenylalanylglycyl-L-valyl-L-α-aspartyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-methionylglycyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-cysteinyl-L-tyrosyl-, cyclic (7→28),(13→33),(17→35)-tris(disulfide)

CAS: 129203-60-7

• Formula: C₈₃H₁₃₃N₂₉O₂₇S₄
• Purity: ≥95%
• Molecular weight: 2097.3822

Iberiotoxin

CAS: 129203-60-7

Selective blocker of the big conductance Ca2+-activated K+ channel.

• Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 4230

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed …

• Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
• Purity: Min. 95%
• Molecular weight: 4,230.8 g/mol

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed …

• Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
• Purity: Min. 95%
• Molecular weight: 4,230.8 g/mol

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the …

• Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
• Purity: Min. 95%
• Molecular weight: 4,230.86 g/mol