CAS 129260-79-3
:Loteprednol
Description:
Loteprednol is a synthetic corticosteroid primarily used for its anti-inflammatory properties, particularly in ophthalmic formulations for treating conditions such as allergic conjunctivitis and post-operative inflammation. It is characterized by its unique structure, which includes a 17α-ethynyl group that enhances its topical potency while minimizing systemic absorption. Loteprednol is known for its rapid onset of action and a favorable safety profile, as it is designed to have reduced side effects compared to traditional corticosteroids. Its mechanism of action involves the inhibition of inflammatory mediators, thereby alleviating symptoms associated with inflammation. The substance is typically formulated as an ophthalmic solution or ointment, allowing for localized treatment with minimal systemic exposure. Loteprednol's pharmacokinetics demonstrate a relatively short half-life, which contributes to its efficacy in treating acute inflammatory conditions. Overall, its design aims to provide effective relief from inflammation while reducing the risk of complications commonly associated with long-term corticosteroid use.
Formula:C24H31ClO7
InChI:InChI=1/C21H27ClO5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,18(25)27-11-22)20(15,2)10-16(24)17(14)19/h5,7,9,14-17,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,17+,19-,20-,21-/m0/s1
InChI key:InChIKey=YPZVAYHNBBHPTO-MXRBDKCISA-N
SMILES:C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])(CC[C@@]2(C(OCCl)=O)O)[H]
Synonyms:- 17a-Hydroxy-11b-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester
- Androsta-1,4-diene-17-carboxylic acid, 11,17-dihydroxy-3-oxo-, chloromethyl ester, (11β,17α)-
- Chloromethyl (11Beta,17Alpha)-11,17-Dihydroxy-3-Oxoandrosta-1,4-Diene-17-Carboxylate
- Loteprednol
- Loteprednol base
- Loteprednol-D5
- Loteprednol API
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