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CAS 129297-22-9

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kijimicin

Description:
Kijimicin is a naturally occurring antibiotic compound that belongs to the class of macrolides. It is produced by certain strains of the bacterium *Micromonospora* and exhibits notable antibacterial properties, particularly against Gram-positive bacteria. Kijimicin is characterized by its complex molecular structure, which includes a large lactone ring and various functional groups that contribute to its biological activity. The compound has been studied for its potential therapeutic applications, especially in treating infections caused by resistant bacterial strains. Its mechanism of action typically involves inhibiting protein synthesis in bacteria, thereby preventing their growth and proliferation. Kijimicin's unique structure and biological properties make it a subject of interest in medicinal chemistry and pharmacology, as researchers explore its potential uses in developing new antibiotics and understanding resistance mechanisms. As with many natural products, the extraction and purification processes can be challenging, but advancements in synthetic methodologies may provide alternative routes for obtaining this compound for further study.
Formula:C37H64O11
InChI:InChI=1/C37H64O11/c1-12-27(38)35(9)18-20(3)37(41,48-35)28-17-19(2)32(44-28)34(8)15-13-25(45-34)26-14-16-36(46-26)24(7)31(43-11)22(5)30(47-36)21(4)29(42-10)23(6)33(39)40/h19-32,38,41H,12-18H2,1-11H3,(H,39,40)/t19-,20-,21-,22-,23-,24+,25+,26-,27+,28+,29+,30+,31+,32+,34-,35-,36-,37-/m0/s1
Synonyms:
  • Kijimicin
  • Kijimycin
  • Monensin, 21,25-deepoxy-16-deethyl-25-de(hydroxymethyl)-12-demethyl-21,24-epoxy-25-ethyl-21-hydroxy-8,16-dimethyl-7-O-methyl-, (8R)-
  • (2S,3R,4S)-4-[(2S,5R,7S,8R,9R,10R)-2-{(2S,2'R,2''S,3'S,3''S,5R,5'R,5''S)-2''-hydroxy-5''-[(1R)-1-hydroxypropyl]-2,3',3'',5''-tetramethyldodecahydro-2,2':5',2''-terfuran-5-yl}-9-methoxy-8,10-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid
  • 4-{2-[2''-hydroxy-5''-(1-hydroxypropyl)-2,3',3'',5''-tetramethyldodecahydro-2,2':5',2''-terfuran-5-yl]-9-methoxy-8,10-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl}-3-methoxy-2-methylpentanoic acid
  • (21S)-21-O,25-Seco-16-deethyl-26-deoxy-12-demethyl-21,24-epoxy-25-ethyl-7-O,8,16,26-tetramethylmonensin
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