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CAS 129300-27-2

:

(+)-FK 1052

Description:
(+)-FK 1052, with the CAS number 129300-27-2, is a chemical compound that belongs to the class of natural products known as macrolides. It is derived from the fermentation of specific strains of bacteria, particularly those in the genus Streptomyces. This compound exhibits notable biological activity, particularly as an immunosuppressant, making it of interest in the field of medicinal chemistry and pharmacology. Its mechanism of action involves the inhibition of T-cell activation, which is crucial for its potential therapeutic applications, especially in organ transplantation and autoimmune diseases. The stereochemistry of (+)-FK 1052 contributes to its biological activity, as the specific configuration can influence its interaction with biological targets. Additionally, like many macrolides, it may possess antibacterial properties, although its primary focus has been on immunosuppressive effects. Research continues to explore its full potential and the implications of its use in clinical settings.
Formula:C18H19N3O
InChI:InChI=1S/C18H19N3O/c1-11-14-5-3-4-6-17(14)21-16(11)8-7-13(18(21)22)9-15-12(2)19-10-20-15/h3-6,10,13H,7-9H2,1-2H3,(H,19,20)/t13-/m1/s1
InChI key:InChIKey=AEKQMJRJRAHOAP-CYBMUJFWSA-N
SMILES:O=C1N2C=3C(C(C)=C2CC[C@@H]1CC4=C(C)N=CN4)=CC=CC3
Synonyms:
  • Pyrido[1,2-a]indol-6(7H)-one, 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-, (R)-
  • Pyrido[1,2-a]indol-6(7H)-one, 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-, (7R)-
  • (7R)-8,9-Dihydro-10-methyl-7-[(4-methyl-1H-imidazol-5-yl)methyl]pyrido[1,2-a]indol-6(7H)-one
  • (R)-8,9-Dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one
  • Pyrido[1,2-a]indol-6(7H)-one, 8,9-dihydro-10-methyl-7-[(4-methyl-1H-imidazol-5-yl)methyl]-, (7R)-
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