CAS 129451-77-0

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative primarily used in the field of molecular biology and biochemistry, particularly in the synthesis of oligonucleotides. This compound features a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at both the 5' and 3' positions. The presence of bulky substituents, such as bis(4-methoxyphenyl) and dimethylsilyl groups, enhances its stability and solubility, making it suitable for various synthetic applications. The cyanoethyl phosphoramidite moiety allows for efficient coupling reactions in oligonucleotide synthesis, facilitating the formation of phosphodiester bonds. Additionally, the compound's structural complexity contributes to its unique reactivity and potential applications in therapeutic and diagnostic technologies. Overall, this substance exemplifies the intricate design often employed in the development of nucleic acid analogs for research and clinical purposes.

Formula: C₄₅H₆₁N₄O₉PSi

InChI: InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-41-40(58-60(10,11)44(5,6)7)38(56-42(41)48-28-26-39(50)47-43(48)51)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

InChI key: InChIKey=UZVSHRLVIXPYEZ-ZMHKPELYSA-N

SMILES: C(OC[C@@H]1[C@@H](O[Si](C(C)(C)C)(C)C)[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O1)N2C(=O)NC(=O)C=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

CAS: 129451-77-0

(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Purity: 97%

Molecular weight: 861.06g/mol

Ref: 54-OR1058205

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite

CAS: 129451-77-0

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite is a modified nucleoside that is commonly used in the synthesis of DNA. It is a monophosphate, diphosphate, and triphosphate analog of uridine. 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite has antiviral and anticancer activity, as well as antitumor properties. This product is available in high purity and high quality.

Formula: C₄₅H₆₁N₄O₉PSi

Purity: Min. 95%

Molecular weight: 861.05 g/mol

Ref: 3D-PT57503