CAS 129460-09-9

Fmoc-Asp-OtBu

Description:

Fmoc-Asp-OtBu, or Fmoc-aspartic acid tert-butyl ester, is a protected form of aspartic acid commonly used in peptide synthesis. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions without interfering with the carboxylic acid group. The tert-butyl (OtBu) ester protects the carboxylic acid, enhancing the stability and solubility of the compound during synthesis. This compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Fmoc-Asp-OtBu is utilized in solid-phase peptide synthesis, where the Fmoc group can be easily removed under basic conditions, facilitating the sequential addition of amino acids. Its structure allows for the introduction of aspartic acid residues into peptides, which are important in various biological functions and applications in drug development. Proper handling and storage are essential, as with many chemical substances, to maintain its integrity and reactivity.

Formula: C₂₃H₂₅NO₆

InChI: InChI=1/C23H25NO6/c1-23(2,3)30-21(27)19(12-20(25)26)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,25,26)/t19-/m0/s1

SMILES: CC(C)(C)OC(=O)[C@H](CC(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12

Synonyms:

• Fmoc-Asp-OBut
• N-α-Fmoc-L-aspartic acid α-tert butyl ester
• (3S)-4-tert-butoxy-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid (non-preferred name)
• Fmoc-L-aspartic acid 1-tert-butyl ester
• L-Fmoc-Aspartic Acid Alpha-Tert-Butyl Ester

1-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate

CAS: 129460-09-9

Formula: C₂₃H₂₅NO₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 411.45

Ref: 3B-F0503

N-Fmoc-L-aspartic acid 1-tert-butyl ester, 95%

CAS: 129460-09-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₃H₂₅NO₆

Purity: 95%

Molecular weight: 411.45

Ref: 02-H62355

Fmoc-Asp-OtBu

CAS: 129460-09-9

Bachem ID: 4012046.

Formula: C₂₃H₂₅NO₆

Purity: 99.3%

Color and Shape: White Powder

Molecular weight: 411.46

Ref: 01-4012046

L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester

CAS: 129460-09-9

Formula: C₂₃H₂₅NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 411.4477

Ref: IN-DA000Z5V

Fmoc-Asp-OtBu

CAS: 129460-09-9

Fmoc-Asp-OtBu

Purity: 98%

Color and Shape: Solid

Molecular weight: 411.45g/mol

Ref: 54-OR36371

Fmoc-Asp(OH)-OtBu

CAS: 129460-09-9

Fmoc-Asp(OH)-OtBu is a synthetic, non-natural amino acid that has been used in the chemical synthesis of lipoproteins. It was incorporated into recombinant human low-density lipoprotein (LDL) and high-density lipoprotein (HDL) to study the effect of acidic hydrolysis on their composition. Fmoc-Asp(OH)-OtBu is a fluorescent compound that can be detected using spectroscopy. It is also used as an amino acid residue in solid-phase peptide synthesis to synthesize peptides with an aspartyl residue at the N terminus.

Formula: C₂₃H₂₅NO₆

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 411.45 g/mol

Ref: 3D-FF33624

Fmoc-Asp(OtBu)-OH

CAS: 129460-09-9

Fmoc-Asp(OtBu)-OH is a chemical compound that belongs to the group of modified amino acids. The synthesis of Fmoc-Asp(OtBu)-OH starts with the reaction of nicotinic acetylcholine, sodium carbonate, and chloride in trifluoroacetic acid. The product is then reacted with a disulfide bond and modified with polymerase chain and saponified. The final modification is achieved by reacting Fmoc-Asp(OtBu)-OH with messenger RNA (mRNA), which produces the desired product. Fmoc-Asp(OtBu)-OH has been shown to have minimal activity, as it does not elute from an ion exchange column under normal conditions. It also has no effect on acetylcholine release in rat hippocampal slices or on morphology when incubated in vitro for 24 hours at 37 degrees Celsius.

Formula: C₂₃H₂₅NO₆

Purity: Min. 98.0 Area-%

Molecular weight: 411.46 g/mol

Ref: 3D-FLD-1713-PI

L-Fmoc-aspartic acid α-t-butyl ester

CAS: 129460-09-9

Formula: C₂₃H₂₅NO₆

Purity: 97%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 411.454

Ref: 10-F041389