CAS 129688-50-2

Minalrestat

Description:

Minalrestat, with the CAS number 129688-50-2, is a chemical compound that functions primarily as an aldose reductase inhibitor. This class of compounds is significant in the context of diabetes management, as they help to reduce the conversion of glucose to sorbitol, thereby potentially mitigating complications associated with diabetic conditions. Minalrestat is characterized by its ability to selectively inhibit the enzyme aldose reductase, which plays a crucial role in the polyol pathway. This inhibition can lead to decreased osmotic and oxidative stress in tissues, particularly in the eyes, nerves, and kidneys, which are commonly affected in diabetic patients. The compound is typically studied for its pharmacological properties and therapeutic potential, particularly in relation to diabetic complications such as retinopathy and neuropathy. Its safety profile, efficacy, and specific pharmacokinetic properties are subjects of ongoing research, contributing to the understanding of its role in diabetes treatment.

Formula: C₁₉H₁₁BrF₂N₂O₄

InChI: InChI=1/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)

InChI key: InChIKey=BMHZAHGTGIZZCT-UHFFFAOYSA-N

SMILES: O=C1C2(C=3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C(F)C3)CC(=O)NC2=O

Synonyms:

• 2-(4-Bromo-2-fluorobenzyl)-6-fluorospiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone
• 2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetrone
• 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(1H),3′-pyrrolidine]-1,2′,3,5′(2H)-tetrone
• Ari 509
• Minalrestat [USAN:INN]
• Spiro(isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrone, 2-((4-bromo-2-fluorophenyl)-methyl)-6-fluoro-
• Spiro[isoquinoline-4(1H),3′-pyrrolidine]-1,2′,3,5′(2H)-tetrone, 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-
• Unii-G44Pe6Qb31
• Way-Ari-509
• Minalrestat

Minalrestat

CAS: 129688-50-2

Minalrestat

Purity: ≥98%

Molecular weight: 449.2g/mol

Ref: 54-BUP02702

Minalrestat

CAS: 129688-50-2

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

Formula: C₁₉H₁₁BrF₂N₂O₄

Purity: 98.64% - 99.88%

Color and Shape: Solid

Molecular weight: 449.2

Ref: TM-T33389