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CAS 129716-58-1

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dofequidar

Description:
Dofequidar, with the CAS number 129716-58-1, is a chemical compound primarily recognized for its role as a multidrug resistance modulator. It is classified as a phenylpiperazine derivative and is notable for its ability to inhibit the activity of certain efflux pumps, particularly P-glycoprotein, which is often overexpressed in cancer cells. This characteristic allows dofequidar to enhance the efficacy of various chemotherapeutic agents by preventing their expulsion from cancer cells, thereby increasing their intracellular concentrations. The compound has been investigated in clinical settings for its potential to improve treatment outcomes in patients with resistant tumors. Dofequidar is typically administered orally and has a favorable pharmacokinetic profile, including good bioavailability. Its chemical structure includes functional groups that contribute to its solubility and interaction with biological membranes. Overall, dofequidar represents a significant advancement in the field of cancer therapy, particularly in addressing the challenges posed by drug resistance.
Formula:C30H31N3O3
InChI:InChI=1/C30H31N3O3/c34-25(22-36-28-15-7-14-27-26(28)13-8-16-31-27)21-32-17-19-33(20-18-32)30(35)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-16,25,29,34H,17-22H2
SMILES:c1ccc(cc1)C(c1ccccc1)C(=O)N1CCN(CC1)CC(COc1cccc2c1cccn2)O
Synonyms:
  • Dofequidar [INN]
  • 1-(Diphenylacetyl)-4-((2RS)-2-hydroxy-3-(5-quinolyloxy)propyl)piperazine
  • Unii-0Bjk6B565B
  • 1-{4-[2-Hydroxy-3-(Quinolin-5-Yloxy)Propyl]Piperazin-1-Yl}-2,2-Diphenylethanone
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