CAS 129731-10-8: (+)-Vorozole

Description:(+)-Vorozole, with the CAS number 129731-10-8, is a selective aromatase inhibitor primarily used in the treatment of hormone-dependent cancers, particularly breast cancer. It functions by inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This mechanism is crucial in managing estrogen-sensitive tumors. The compound is characterized by its chiral nature, with the (+) designation indicating its specific optical activity. Vorozole is typically administered orally and has been studied for its pharmacokinetics, including absorption, distribution, metabolism, and excretion. Its efficacy and safety profile make it a subject of interest in both clinical and research settings. Additionally, Vorozole's chemical structure includes a triazole ring, which is significant for its biological activity. Overall, (+)-Vorozole represents an important therapeutic option in oncology, particularly for postmenopausal women with estrogen receptor-positive breast cancer.

Formula:C₁₆H₁₃ClN₆

InChI:InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1

InChI key:InChIKey=XLMPPFTZALNBFS-INIZCTEOSA-N

SMILES:ClC1=CC=C(C=C1)C(C=2C=CC=3N=NN(C3C2)C)N4N=CN=C4

Synonyms:
1H-Benzotriazole, 6-[(4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-, (S)-
Vorozole
6-[(S)-(4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-1H-benzotriazole
1H-Benzotriazole, 6-[(S)-(4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-
R 83842