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CAS 129732-90-7

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O(6)-benzyl-2'-deoxyguanosine

Description:
O(6)-benzyl-2'-deoxyguanosine is a modified nucleoside that features a benzyl group attached to the oxygen atom at the 6-position of the guanine base. This compound is a derivative of 2'-deoxyguanosine, which is one of the four nucleosides that make up DNA. The presence of the benzyl group enhances its lipophilicity, potentially influencing its interaction with biological membranes and proteins. O(6)-benzyl-2'-deoxyguanosine is of interest in biochemical research, particularly in studies related to DNA repair mechanisms and the effects of alkylating agents on nucleic acids. Its structure allows it to participate in various biochemical reactions, making it a useful tool in molecular biology and medicinal chemistry. Additionally, the compound may exhibit unique pharmacological properties, which could be explored for therapeutic applications. As with many nucleoside analogs, its stability, solubility, and reactivity are critical factors that determine its utility in research and potential clinical applications.
Formula:C17H19N5O4
InChI:InChI=1/C17H19N5O4/c18-17-20-15-14(16(21-17)25-8-10-4-2-1-3-5-10)19-9-22(15)13-6-11(24)12(7-23)26-13/h1-5,9,11-13,23-24H,6-8H2,(H2,18,20,21)/t11-,12+,13+/m0/s1
Synonyms:
  • O6-B-dG
  • Guanosine, 2'-deoxy-6-O-(phenylmethyl)-
  • 6-(benzyloxy)-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-2-amine
  • O(6)-Benzyl-2'-deoxyguanosine
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Found 3 products.
  • O6-Benzyl-2''-deoxyguanosine
    Glentham
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    O6-Benzyl-2''-deoxyguanosine

    CAS:

    Ref: 7W-GC7641

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  • O6-Benzyl-2'-deoxyguanosine
    TRC
    + Info

    O6-Benzyl-2'-deoxyguanosine

    Controlled Product
    CAS:
    <p>Applications Protected Deoxyguanosine.<br>References Kokkinakis, D., et al.: Clin. Cancer Res., 9, 3801 (2003), Coulter, R., et al.: Chem. Res. Toxicol., 20, 1966 (2007),<br></p>
    Formula:C17H19N5O4
    Color and Shape:Neat
    Molecular weight:357.36

    Ref: TR-B234700

    5mg
    183.00€
    10mg
    302.00€
  • 6-O-Benzyl-2'-deoxyguanosine
    Biosynth
    + Info

    6-O-Benzyl-2'-deoxyguanosine

    CAS:
    <p>6-O-Benzyl-2'-deoxyguanosine is a synthetic nucleoside analog that inhibits the synthesis of DNA. It is used in animal studies as a pancreatic carcinogen, and has been shown to inhibit tumor growth in mice. This drug specifically binds to DNA at the O6 position of guanine and methylates the adjacent cytosine residue, thereby preventing synthesis of DNA. 6-O-Benzyl-2'-deoxyguanosine also inhibits the activity of an enzyme called methyltransferase, which converts S-adenosylmethionine into S-adenosylhomocysteine, an intermediate in one of the pathways that produce methionine from homocysteine. This inhibition leads to an accumulation of methionine and its metabolites, including homocysteine and cystathione beta synthase, which can cause cell death.</p>
    Formula:C17H19N5O4
    Purity:Min. 95%
    Molecular weight:357.36 g/mol

    Ref: 3D-NB16627

    5mg
    486.00€
    10mg
    729.00€