CAS 129735-00-8

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

Description:

8-Bromoadenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt, with CAS number 129735-00-8, is a synthetic nucleotide analog that serves as a potent biochemical tool in research, particularly in the study of cyclic nucleotide signaling pathways. This compound features a bromine atom at the 8-position of the adenosine moiety, which enhances its biological activity compared to its unmodified counterparts. The cyclic monophosphate structure is crucial for mimicking the natural signaling molecules, allowing it to interact with specific receptors and enzymes involved in cellular signaling. The phosphorothioate modification provides increased stability against enzymatic degradation, making it suitable for in vitro and in vivo studies. As a sodium salt, it is typically soluble in aqueous solutions, facilitating its use in various biochemical assays. Its RP-isomer designation indicates a specific stereochemistry that is important for its biological activity. Overall, this compound is valuable in pharmacological research, particularly in understanding the roles of cyclic nucleotides in cellular processes.

Formula: C₁₀H₁₀BrN₅NaO₅PS

Synonyms:

• Rp-8-Br-Camps
• Rp-8-Br-Camps, Na
• Rp-8-Br-Camps Sodium Salt
• 8-Bromoadenosine-3’,5’-Cyclicmonophosphorothioate,Rp-Isomer(Rp-8-Br-Camps),Sodiumsalt
• 8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate Sodium Salt, Rpisomer
• 8-Bromoadenosine 3',5'-Cyclic Monophosphothioate, Rp-Isomer Sodium Salt
• 8-Br-Camps Na, Rp-Isomer
• 8-BROMOADENOSINE-3',5'-CYCLIC * MONOPHOSPHOROTHIOAT
• 8-Bromoadenosine-3'',5''-cyclic monophosphothioate Rp isomer
• 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
• ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-BROMO-, RP-ISOMER, SODIUM SALT

8-Bromoadenosine 3'',5''-cyclic monophosphorothioate, Rp-isomer sodium salt

CAS: 129735-00-8

Ref: 7W-GN6710

8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium

CAS: 129735-00-8

8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt (8-BrAMP) is an activated analog of adenosine that binds to the cyclase enzyme and inhibits its activity. It has been shown to inhibit the production of epidermal growth factor in a model system. 8-BrAMP also blocks the synthesis of cyclic nucleotides by inhibiting cyclic nucleotide phosphodiesterase, which results in increased levels of cAMP. 8-BrAMP has been shown to inhibit HIV infection by acting as a transcription-polymerase chain inhibitor and blocking HIV mRNA synthesis. The drug also inhibits cell lysis by binding to calmodulin and β-catenin.

Formula: C₁₀H₁₁BrN₅O₅PS•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 447.16 g/mol

Ref: 3D-NB13568