CAS 1297537-33-7

5-Acetyl-N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-1H-pyrazole-3-carboxamide

Description:

5-Acetyl-N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-1H-pyrazole-3-carboxamide, with CAS number 1297537-33-7, is a synthetic organic compound characterized by its complex pyrazole structure, which includes multiple functional groups such as an acetyl group and a carboxamide. This compound features a chiral center, contributing to its stereochemistry, and exhibits potential biological activity due to the presence of the pyrazole moiety, which is often associated with pharmacological properties. The chlorinated phenyl group enhances its lipophilicity, potentially influencing its interaction with biological targets. The compound's solubility, stability, and reactivity can vary based on environmental conditions and the presence of other substances. Its synthesis typically involves multi-step organic reactions, and it may be of interest in medicinal chemistry for its potential therapeutic applications. As with many pyrazole derivatives, it may exhibit anti-inflammatory, analgesic, or other bioactive properties, warranting further investigation in drug development contexts.

Formula: C₁₉H₁₇ClN₆O₂

InChI: InChI=1S/C19H17ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-/m0/s1

InChI key: InChIKey=GMBPVBVTPBWIKC-NSHDSACASA-N

SMILES: C([C@@H](NC(=O)C=1C=C(C(C)=O)NN1)C)N2N=C(C=C2)C3=CC(Cl)=C(C#N)C=C3

Synonyms:

• 1H-Pyrazole-3-carboxamide, 5-acetyl-N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-
• 5-Acetyl-N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-1H-pyrazole-3-carboxamide
• (S)-5-Acetyl-N-[1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl]-1H-pyrazole-3-carboxamide
• ORM 15341
• ORM-15341(Ketodarolutamide)
• (S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-phenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide
• Ketodarolutamide

ORM-15341

CAS: 1297537-33-7

ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)

Formula: C₁₉H₁₇ClN₆O₂

Purity: 98.01%

Color and Shape: Solid

Molecular weight: 396.83

Ref: TM-T12323

Ketodarolutamide

CAS: 1297537-33-7

Formula: C₁₉H₁₇ClN₆O₂

Molecular weight: 396.84

Ref: 4Z-D-245003

ORM-15341

CAS: 1297537-33-7

ORM-15341

Formula: C₁₉H₁₇ClN₆O₂

Purity: ≥98%

Color and Shape: solid

Molecular weight: 396.83g/mol

Ref: 54-BUP04175

ORM-15341

CAS: 1297537-33-7

Applications ORM-15341 is a metabolite of Darolutamide. Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.
References Sugawara, T., et al.: Int. J. Cancer, 145, 1382 (2019); Yu, J., et al.: Eur. J. Med. Chem., 182, 111608 (2019)

Formula: C₁₉H₁₇ClN₆O₂

Color and Shape: Neat

Molecular weight: 396.83

Ref: TR-O410010

ORM-15341

CAS: 1297537-33-7

Please enquire for more information about ORM-15341 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₉H₁₇ClN₆O₂

Purity: Min. 95%

Molecular weight: 396.83 g/mol

Ref: 3D-XBC53733

Darolutamide Amide Impurity

CAS: 1297537-33-7

Formula: C₁₉H₁₇ClN₆O₂

Molecular weight: 396.84

Ref: ST-EA-CP-D68007