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CAS 129791-92-0

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Rifalazil

Description:
Rifalazil is a synthetic antibiotic belonging to the rifamycin class, primarily known for its antibacterial properties. It is characterized by its ability to inhibit bacterial RNA synthesis, making it effective against a range of Gram-positive and some Gram-negative bacteria. The compound is particularly noted for its activity against Mycobacterium tuberculosis, the causative agent of tuberculosis, and has been investigated for its potential use in treating various bacterial infections. Rifalazil exhibits good oral bioavailability and is metabolized in the liver, with its pharmacokinetics influenced by factors such as age and liver function. Its mechanism of action involves binding to the bacterial RNA polymerase, thereby preventing transcription. While it shows promise in clinical applications, resistance development is a concern, as with many antibiotics. Additionally, its safety profile and side effects are important considerations in therapeutic use. Overall, Rifalazil represents a significant advancement in antibiotic therapy, particularly in the context of resistant bacterial strains.
Formula:C51H64N4O13
InChI:InChI=1S/C51H64N4O13/c1-24(2)23-54-16-18-55(19-17-54)32-21-33(57)39-35(22-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-20-15-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)25(3)13-12-14-26(4)50(63)53-41(48)45(37)61/h12-15,20-22,24-25,27-29,34,42-43,46,57-60H,16-19,23H2,1-11H3,(H,53,63)/b13-12+,20-15-,26-14+/t25-,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1
InChI key:InChIKey=UEFHFKKWYKVLDC-QEOGJXKSSA-N
SMILES:O=C1C=2C=3C=4C(=C5C(=O)C3C(O)=C(C)C2O[C@]1(C)O/C=C\[C@](OC)([C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(\C)/C(=O)N5)[H])OC=6C(N4)=C(O)C=C(C6)N7CCN(CC(C)C)CC7
Synonyms:
  • (2S,16Z,18E,20S,21S,22R,23R,24S,25S,26S,27S,28E)-5,12,21,23-tetrahydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-1,6,15-trioxo-1,2-dihydro-6H,13H-2,7-(epoxypentadeca[1,11,13]trienoazeno)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate
  • (2S,16Z,18E,20S,21S,22R,23S,24S,25S,26S,27S,28E)-5,12,21,23-tetrahydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-1,6,15-trioxo-1,2-dihydro-6H,13H-2,7-(epoxypentadeca[1,11,13]trienoazeno)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate
  • 1′,4-Didehydro-1-deoxy-1,4-dihydro-3′-hydroxy-5′-[4-(2-methylpropyl)-1-piperazinyl]-1-oxorifamycin VIII
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)-6H-benzofuro[4,5-a]phenoxazine, rifamycin VIII deriv.
  • 3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
  • 5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
  • Abi 1648
  • Ami 1648
  • Isobutylpiperazinyl rifa
  • Krm 1648
  • See more synonyms
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Found 4 products.
  • CymitQuimica logo
    Apollo Scientific
    + Info

    Rifalazil

    CAS:
    Rifalazil
    Purity:≥95%
    Molecular weight:941.07g/mol

    Ref: 54-BUP21729

    2mg
    144.00€
  • Rifalazil
    Targetmol
    + Info

    Rifalazil

    CAS:
    <p>Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.</p>
    Formula:C51H64N4O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:941.07

    Ref: TM-T16749

  • Rifalazil
    TRC
    + Info

    Rifalazil

    Controlled Product
    CAS:
    <p>Applications Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis.<br>References Rothstein D. M., at al., Expert Opin. Investig. Drugs: 12, 255-271 (2003)<br></p>
    Formula:C51H64N4O13
    Color and Shape:Neat
    Molecular weight:941.073

    Ref: TR-R504000

    100mg
    2,087.00€
  • Rifalazil
    Biosynth
    + Info

    Rifalazil

    CAS:
    <p>Rifalazil is a nonsteroidal anti-inflammatory drug that inhibits the activity of cyclooxygenase (COX) and lipoxygenase enzymes. It is used to treat bowel disease and has been shown to be effective against human pathogens, such as Streptococcus species. Rifalazil also inhibits the production of inflammatory cytokines in human macrophages, which may be linked to its clinical relevance for inflammatory bowel disease. This drug is metabolized by cytochrome P450 enzymes and has pharmacokinetic properties that are independent of renal function.</p>
    Formula:C51H64N4O13
    Purity:Min. 95%
    Molecular weight:941.07 g/mol

    Ref: 3D-FR170888

    50mg
    1,378.00€
    100mg
    2,440.00€