CAS 129809-09-2

Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2

Description:

The chemical substance with the name "Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2" is a peptide, specifically a modified form of a polypeptide that includes an acetyl group (Ac) at the N-terminus and an amide group (NH2) at the C-terminus. This peptide consists of a sequence of amino acids: leucine (Leu), aspartic acid (Asp), glutamine (Gln), tryptophan (Trp), phenylalanine (Phe), and glycine (Gly). The presence of the acetyl group enhances its stability and solubility, while the amide group can influence its biological activity and interactions. Peptides like this one are often studied for their potential roles in biological processes, including signaling pathways and therapeutic applications. The CAS number 129809-09-2 uniquely identifies this specific compound in chemical databases, facilitating research and regulatory processes. Overall, the characteristics of this peptide suggest it may have interesting biochemical properties, making it a subject of interest in fields such as biochemistry, pharmacology, and molecular biology.

Formula: C₃₉H₅₁N₉O₁₀

InChI: InChI=1/C39H51N9O10/c1-21(2)15-28(44-22(3)49)37(56)48-31(18-34(52)53)39(58)45-27(13-14-32(40)50)36(55)47-30(17-24-19-42-26-12-8-7-11-25(24)26)38(57)46-29(35(54)43-20-33(41)51)16-23-9-5-4-6-10-23/h4-12,19,21,27-31,42H,13-18,20H2,1-3H3,(H2,40,50)(H2,41,51)(H,43,54)(H,44,49)(H,45,58)(H,46,57)(H,47,55)(H,48,56)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CC(=O)O)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N)O)O)O)O)O)O)N=C(C)O

Synonyms:

• R 396
• Acetylleucyl-aspartyl-glutaminyl-tryptophyl-phenylalanyl-glycine amide
• Acleu-asp-gln-trp-phe-glynh2
• R396
• Glycinamide, N-acetyl-L-leucyl-L-alpha-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-
• N-acetyl-L-leucyl-L-alpha-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanylglycinamide
• AC-LEU-ASP-GLN-TRP-PHE-GLY-NH2
• Glycinamide, N-acetyl-L-leucyl-L-α-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-
• NEUROKININ NK-2 RECEPTOR ANTAGONIST
• Ac-LDQWFG-amide
• Ac-L-Leu-L-Asp-L-Gln-L-Trp-L-Phe-Gly-NH2

R 396

CAS: 129809-09-2

R 396 (Acleu-asp-gln-trp-phe-glynh2) is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.

Formula: C₃₉H₅₁N₉O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 805.88

Ref: TM-T24697

Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2

CAS: 129809-09-2

Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2 is a peptide that was found to inhibit the activity of vasoactive intestinal peptide (VIP). It binds to VIP with high affinity and competitively inhibits its binding to VIP receptors. Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2 has an inhibitory effect on the maximal response of VIP in tissues, such as the intestine. This peptide also has an irritant effect on the intestine, which may be due to its competitive inhibition of VIP receptor sites. Ac-Leu-Asp-Gln-Trp-Phe Gly NH2 has been shown to have a concentration response curve for inhibiting the activity of Vip.

Formula: C₃₉H₅₁N₉O₁₀

Purity: Min. 95%

Molecular weight: 805.88 g/mol

Ref: 3D-FA108396