CAS 129981-36-8

Sampatrilat

Description:

Sampatrilat is a synthetic compound that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors, primarily developed for the treatment of hypertension and heart failure. It functions by inhibiting the enzyme ACE, which plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), thereby reducing the production of angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, decreased blood pressure, and reduced workload on the heart. Sampatrilat is characterized by its ability to improve cardiovascular outcomes and is often studied for its potential benefits in various cardiovascular diseases. The compound has a specific molecular structure that contributes to its pharmacological activity, and it is typically administered orally. As with many ACE inhibitors, potential side effects may include cough, elevated potassium levels, and hypotension. Research into Sampatrilat has also explored its effects on renal function and its role in protecting against organ damage in hypertensive patients. However, its clinical use may vary based on regulatory approvals and ongoing studies.

Formula: C₂₆H₄₀N₄O₉S

InChI: InChI=1S/C26H40N4O9S/c1-40(38,39)30-20(6-2-5-13-27)22(32)28-16-18(23(33)34)15-26(11-3-4-12-26)25(37)29-21(24(35)36)14-17-7-9-19(31)10-8-17/h7-10,18,20-21,30-31H,2-6,11-16,27H2,1H3,(H,28,32)(H,29,37)(H,33,34)(H,35,36)/t18-,20-,21-/m0/s1

InChI key: InChIKey=LPUDGHQMOAHMMF-JBACZVJFSA-N

SMILES: C([C@@H](CNC([C@H](CCCCN)NS(C)(=O)=O)=O)C(O)=O)C1(C(N[C@@H](CC2=CC=C(O)C=C2)C(O)=O)=O)CCCC1

Synonyms:

• beta-Alanine, 2-((1-(((1-carboxy-2-(4-hydroxyphenyl)ethyl)amino)carbonyl)cyclopentyl)methyl)-N-(N2-(methylsulfonyl)-L-lysyl)-, (S-(R*,R*))-
• N-({1-[(2R)-3-carboxy-2-{[N~2~-(methylsulfonyl)-L-lysyl]amino}propyl]cyclopentyl}carbonyl)-L-tyrosine
• L-Tyrosine, N2-(methylsulfonyl)-L-lysyl-1-[(2S)-3-amino-2-carboxypropyl]cyclopentanecarbonyl-
• N-(1-(2-Carboxy-3-(N(2)-mesyllysylamino)propyl)-1-cyclopentylcarbonyl)tyrosine
• (S-(R*,R*))-2-((1-(((1-Carboxy-2-(4-hydroxyphenyl)ethyl)amino)carbonyl)cyclopentyl)methyl)-N-(N2-(methylsulfonyl)-L-lysyl)-beta-Alanine
• UK 81252
• β-Alanine, 2-[[1-[[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl]cyclopentyl]methyl]-N-[N2-(methylsulfonyl)-L-lysyl]-, [S-(R*,R*)]-
• N2-(Methylsulfonyl)-L-lysyl-1-[(2S)-3-amino-2-carboxypropyl]cyclopentanecarbonyl-L-tyrosine
• N-((1-((S)-3-((S)-6-Amino-2-methanesulfonamidohexanamido)-2-carboxypropyl)cyclopentyl)carbonyl)-L-tyrosine
• Sampatrilat
• UK 81,252

Sampatrilat

CAS: 129981-36-8

Sampatrilat, an oral vasopeptidase inhibitor, more potently blocks C-domain ACE (Ki=13.8 nM) over N-domain (Ki=171.9 nM).

Formula: C₂₆H₄₀N₄O₉S

Purity: 98%

Color and Shape: Solid

Molecular weight: 584.68

Ref: TM-T16840