CAS 1300031-49-5

I-BET151

Description:

I-BET151 is a small molecule inhibitor primarily known for its role in targeting the bromodomain and extraterminal (BET) family of proteins, which are involved in regulating gene expression. This compound has garnered attention in the field of cancer research due to its potential to disrupt the interaction between BET proteins and acetylated lysines on histones, thereby influencing transcriptional regulation. I-BET151 is characterized by its ability to selectively inhibit BET proteins, particularly BRD4, which plays a crucial role in the progression of various cancers. The compound is typically studied for its effects on cell proliferation and differentiation, as well as its potential therapeutic applications in hematological malignancies and solid tumors. In terms of physical properties, I-BET151 is a solid at room temperature and is often used in biochemical assays to evaluate its efficacy and mechanism of action. Its development represents a significant advancement in targeted cancer therapies, highlighting the importance of epigenetic regulation in oncogenesis.

Formula: C₂₃H₂₁N₅O₃

InChI: InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1

InChI key: InChIKey=VUVUVNZRUGEAHB-CYBMUJFWSA-N

SMILES: [C@H](C)(N1C=2C=3C(=CC(=C(OC)C3)C=4C(C)=NOC4C)N=CC2NC1=O)C5=CC=CC=N5

Synonyms:

• GSK1210151
• 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one
• 2H-Imidazo[4,5-c]quinolin-2-one, 7-(3,5-dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-
• I-BET 151
• I-BET151
• GSK 1210151A
• I-BET 151/GSK 1210151A
• 7-(3,5-Dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-(2-pyridinyl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
• 7-(3,5-diMethylisoxazol-4-yl)-8-Methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-iMidazo[4,5-c]quinolin-2(3H)-one
• GSK1210151A (I-BET151)
• 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2

2H-Imidazo[4,5-c]quinolin-2-one, 7-(3,5-dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-

CAS: 1300031-49-5

Formula: C₂₃H₂₁N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.4445

Ref: IN-DA000TW9

I-BET151

CAS: 1300031-49-5

I-BET151

Purity: ≥95%

Molecular weight: 415.44g/mol

Ref: 54-BUP06956

I-BET151

CAS: 1300031-49-5

I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).

Formula: C₂₃H₂₁N₅O₃

Purity: 97.34% - 99.63%

Color and Shape: Solid

Molecular weight: 415.44

Ref: TM-T2120

I-BET151

CAS: 1300031-49-5

Purity: 98%

Molecular weight: 415.453002929688

Ref: 10-F861699

I-BET 151

Controlled Product

CAS: 1300031-49-5

Applications I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play key roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activities upon administration.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Seal, J., et al.L Bioorg. Medn. Chem. Letters., 22, 2968 (2012); Mirguet, O., et al.: Bioorg. Medn. Chem. Letters, 22, 2963 (2012); Dawson, M.A., et al.: Nature., 478, 529 (2011);

Formula: C₂₃H₂₁N₅O₃

Color and Shape: Neat

Molecular weight: 415.44

Ref: TR-I120050

I-BET 151

CAS: 1300031-49-5

Isoxazole class pan-BET family inhibitor

Formula: C₂₃H₂₁N₅O₃

Purity: Min. 95%

Molecular weight: 415.44 g/mol

Ref: 3D-FD43075