CAS 1300037-86-8

Tapentadol O-β-D-glucuronide

CAS: 1300037-86-8

Ref: 7W-GC1337

Tapentadol O-b-D-Glucuronide

Controlled Product

CAS: 1300037-86-8

Applications A metabolite of Tapentadol (T007200).
References Terlinden, R., et al.: Eur. J. Drug Metab. Pharmacokinet., 32, 163 (2007), Tzschentke, T., et al.: J. Pharmacol. Exp. Ther., 323, 256 (2007), Wade, W., et al.: Clin. Ther., 31, 2804 (2009),

Formula: C₂₀H₃₁NO₇

Color and Shape: Neat

Molecular weight: 397.46

Ref: TR-T007210

Tapentadol O-b-D-Glucuronide (1 mg/ml in Methanol)

Controlled Product

CAS: 1300037-86-8

Formula: C₂₀H₃₁NO₇

Color and Shape: Colourless

Molecular weight: 397.46

Ref: TR-KIT0155

Tapentadol-d5 O-β-D-Glucuronide

Controlled Product

CAS: 1300037-86-8

Formula: C₂₀D₅H₂₆NO₇

Color and Shape: Neat

Molecular weight: 402.493

Ref: TR-T007212

Tapentadol-²-D-glucuronide solution

Controlled Product

CAS: 1300037-86-8

Tapentadol is a centrally acting analgesic agent that binds to the µ-opioid receptor. Tapentadol is metabolized in the liver by glucuronidation and sulfation. Tapentadol 2-D-glucuronide is an active metabolite of tapentadol and exhibits a higher affinity for µ-opioid receptors than tapentadol. The clinical relevance of this metabolite has not been studied, but concentrations of tapentadol 2-D-glucuronide in plasma may be useful for monitoring therapeutic effects and for assessing side effects such as respiratory depression. It is believed that tapentadol 2-D-glucuronide binds to opioid receptors in the brain, spinal cord, and peripheral nervous system, which accounts for its analgesic properties. The clinical development of tapentadol was designed to assess its safety and efficacy in pediatric patients (ages 6–17 years). Plasma concentrations were measured using liquid chromatography

Formula: C₂₀H₃₁NO₇

Purity: Min. 95%

Molecular weight: 397.46 g/mol

Ref: 3D-ACC03786