CAS 130017-40-2

3-[[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-2(1H)-quinazolinone

Description:

The chemical substance known as 3-[[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-2(1H)-quinazolinone, with the CAS number 130017-40-2, is a synthetic compound that belongs to the class of quinazolinones. This compound features a complex structure characterized by a quinazoline core, which is fused with a piperidine moiety, contributing to its potential biological activity. The presence of methoxy groups on the quinazoline ring enhances its lipophilicity and may influence its interaction with biological targets. Typically, compounds of this nature are investigated for their pharmacological properties, including potential applications in treating various diseases, particularly in the fields of oncology and neurology. The specific stereochemistry and functional groups present in this molecule can significantly affect its solubility, stability, and reactivity, making it a subject of interest in medicinal chemistry research. As with many synthetic organic compounds, understanding its characteristics requires thorough analysis through techniques such as NMR, mass spectrometry, and X-ray crystallography.

Formula: C₂₄H₂₇N₅O₃

InChI: InChI=1S/C24H27N5O3/c1-31-21-11-18-20(12-22(21)32-2)25-15-26-23(18)28-9-7-16(8-10-28)13-29-14-17-5-3-4-6-19(17)27-24(29)30/h3-6,11-12,15-16H,7-10,13-14H2,1-2H3,(H,27,30)

InChI key: InChIKey=GWXCGEJJQFHPPA-UHFFFAOYSA-N

SMILES: O(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCC(CN4CC=5C(NC4=O)=CC=CC5)CC3

Synonyms:

• 3-[[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-2(1H)-quinazolinone
• 2(1H)-Quinazolinone, 3-[[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-
• K-756 >=98% (HPLC)
• K-756

K-756

CAS: 130017-40-2

K-756

Purity: ≥98%

Molecular weight: 433.5g/mol

Ref: 54-BUP08589

K-756

CAS: 130017-40-2

K-756 is a chemokine that is produced by tumor cells. It stabilizes β-catenin and inhibits the proteasome pathway, which leads to cancer progression. K-756 is orally bioavailable and potently activates β-catenin in a dose-dependent manner in both cultured tumor cells and animal models. In vivo studies show that K-756 stabilizes β-catenin, reduces tumor growth, and induces apoptosis of tumor cells. The molecule also stabilizes activated β-catenin in the microenvironment of the tumor.

Formula: C₂₄H₂₇N₅O₃

Purity: Min. 95%

Molecular weight: 433.5 g/mol

Ref: 3D-FFA01740

K-756

CAS: 130017-40-2

K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).

Formula: C₂₄H₂₇N₅O₃

Purity: 99.81%

Color and Shape: Solid

Molecular weight: 433.5

Ref: TM-T15639