CAS 130018-76-7
:(S)-Cetirizine
Description:
(S)-Cetirizine is an antihistamine commonly used to alleviate allergy symptoms such as sneezing, runny nose, and itching. It is the active enantiomer of cetirizine, which is a second-generation antihistamine derived from piperazine. This compound exhibits a high affinity for peripheral H1 receptors, effectively blocking the action of histamine, a key mediator in allergic reactions. (S)-Cetirizine is characterized by its relatively low sedative effects compared to first-generation antihistamines, making it suitable for daytime use. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The substance is known for its favorable pharmacokinetic profile, including a long half-life, which allows for once-daily dosing. Additionally, (S)-Cetirizine is generally well-tolerated, with a low incidence of adverse effects, although some individuals may experience drowsiness or dry mouth. Its chemical structure includes a carboxylic acid group, contributing to its solubility and bioavailability. Overall, (S)-Cetirizine is an effective and widely used medication in the management of allergic conditions.
Formula:C21H25ClN2O3
InChI:InChI=1/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m0/s1
SMILES:c1ccc(cc1)[C@@H](c1ccc(cc1)Cl)N1CCN(CC1)CCOCC(=O)O
Synonyms:- (S)-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid
- Dextrocetirizin
- Dextrocetirizine
- (2-{4-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
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