CymitQuimica logo

CAS 130018-77-8

:

(-)-Cetirizine

Description:
(-)-Cetirizine is an antihistamine commonly used to alleviate allergy symptoms such as sneezing, runny nose, and itching. It is a second-generation antihistamine, which means it is less likely to cause sedation compared to first-generation antihistamines. The substance is characterized by its selective antagonism of peripheral H1 receptors, effectively blocking the action of histamine, a compound involved in allergic reactions. Chemically, (-)-Cetirizine is a chiral molecule, with its active form being the enantiomer that exhibits the desired therapeutic effects. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. The compound is soluble in water and exhibits good bioavailability. Additionally, (-)-Cetirizine may have mild anticholinergic properties, which can contribute to its efficacy in treating allergic conditions. Its safety profile is generally favorable, with common side effects including drowsiness, dry mouth, and gastrointestinal disturbances. Overall, (-)-Cetirizine is an effective and widely used medication for managing allergic symptoms.
Formula:C21H25ClN2O3
InChI:InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
InChI key:InChIKey=ZKLPARSLTMPFCP-OAQYLSRUSA-N
SMILES:[C@H](N1CCN(CCOCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3
Synonyms:
  • (-)-Cetirizine
  • (2-(4-((R-p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid
  • (2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
  • (2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
  • (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
  • (R)-Cetirizine
  • 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
  • Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, (R)-
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 4 products.