CAS 130018-77-8

(-)-Cetirizine

Description:

(-)-Cetirizine is an antihistamine commonly used to alleviate allergy symptoms such as sneezing, runny nose, and itching. It is a second-generation antihistamine, which means it is less likely to cause sedation compared to first-generation antihistamines. The substance is characterized by its selective antagonism of peripheral H1 receptors, effectively blocking the action of histamine, a compound involved in allergic reactions. Chemically, (-)-Cetirizine is a chiral molecule, with its active form being the enantiomer that exhibits the desired therapeutic effects. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. The compound is soluble in water and exhibits good bioavailability. Additionally, (-)-Cetirizine may have mild anticholinergic properties, which can contribute to its efficacy in treating allergic conditions. Its safety profile is generally favorable, with common side effects including drowsiness, dry mouth, and gastrointestinal disturbances. Overall, (-)-Cetirizine is an effective and widely used medication for managing allergic symptoms.

Formula: C₂₁H₂₅ClN₂O₃

InChI: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1

InChI key: InChIKey=ZKLPARSLTMPFCP-OAQYLSRUSA-N

SMILES: [C@H](N1CCN(CCOCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• (-)-Cetirizine
• (2-(4-((R-p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid
• (2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
• (2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
• (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
• (R)-Cetirizine
• 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
• Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
• Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
• Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, (R)-
• Unii-6U5Ea9Rt2O
• Xusal

Levocetirizine Dihydrochloride

CAS: 130018-77-8, 130018-87-0

Formula: C₂₁H₂₅ClN₂O₃·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 461.81

Ref: 3B-L0264

Levocetirizine

CAS: 130018-77-8

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.

Formula: C₂₁H₂₅ClN₂O₃

Purity: 98% - 99.94%

Color and Shape: White Powder

Molecular weight: 388.89

Ref: TM-T1469

Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

CAS: 130018-77-8

Formula: C₂₁H₂₅ClN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 388.8878

Ref: IN-DA000TX4

Levocetirizine

CAS: 130018-77-8

Levocetirizine

Purity: ≥98%

Molecular weight: 388.89g/mol

Ref: 54-BUP10390