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CAS 130018-87-0

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Levocetirizine dihydrochloride

Description:
Levocetirizine dihydrochloride is an antihistamine medication primarily used to alleviate symptoms associated with allergic rhinitis and chronic urticaria. It is the active enantiomer of cetirizine, which means it is one of two mirror-image forms of the molecule, specifically the R-enantiomer, known for its enhanced efficacy and reduced side effects. The substance is a white to off-white crystalline powder that is soluble in water, making it suitable for various formulations, including tablets and oral solutions. Levocetirizine acts by selectively inhibiting peripheral H1 receptors, thereby reducing the effects of histamine, a compound involved in allergic reactions. Its pharmacokinetics indicate a rapid onset of action, with a relatively long duration of effect, allowing for once-daily dosing. Common side effects may include drowsiness, fatigue, and dry mouth, although it is generally well-tolerated. Due to its safety profile, it is often preferred for use in both adults and children.
Formula:C21H27Cl3N2O3
InChI:InChI=1/C21H25ClN2O2.ClH/c22-19-10-8-18(9-11-19)21(17-5-2-1-3-6-17)24-15-13-23(14-16-24)12-4-7-20(25)26;/h1-3,5-6,8-11,21H,4,7,12-16H2,(H,25,26);1H/t21-;/m0./s1
InChI key:InChIKey=PGLIUCLTXOYQMV-GHVWMZMZSA-N
SMILES:[C@H](N1CCN(CCOCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3.Cl
Synonyms:
  • (R)-(-)-Cetirizine hydrochloride
  • (R)-Cetirizine dihydrochloride
  • 4-{4-[(S)-(4-Chlorophenyl)(Phenyl)Methyl]Piperazin-1-Yl}Butanoic Acid Hydrochloride (1:1)
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2)
  • Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride, (R)-
  • Acetic acid, [2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride
  • Allear
  • Allercet
  • Leocetirizine Hydrochloride
  • Levo Cetirzine Dihydrochloride
  • See more synonyms
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