CAS 13002-65-8

(E)-Tamoxifen

Description:

(E)-Tamoxifen is a synthetic compound primarily used in the treatment and prevention of estrogen receptor-positive breast cancer. It is classified as a selective estrogen receptor modulator (SERM), which means it can act as an estrogen antagonist in breast tissue while exhibiting estrogen-like effects in other tissues, such as bone and the endometrium. The chemical structure of (E)-Tamoxifen features a triphenylethylene backbone, which contributes to its ability to bind to estrogen receptors. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. The compound is also characterized by its lipophilicity, which influences its absorption and distribution in the body. Common side effects may include hot flashes, nausea, and an increased risk of thromboembolic events. Due to its mechanism of action, (E)-Tamoxifen has been pivotal in adjuvant therapy for breast cancer and has also been studied for its potential use in other hormone-related conditions.

Formula: C₂₆H₂₉NO

InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25+

InChI key: InChIKey=NKANXQFJJICGDU-OCEACIFDSA-N

SMILES: C(=C(\CC)/C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3

Synonyms:

• (E)-Tamoxifen
• 2-[4-[(1E)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
• Brn 2062021
• Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (E)-
• Ethanamine, 2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
• Ethanamine, 2-[4-[(1E)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
• Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (E)-
• Ethylamine, N,N-dimethyl-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-, (E)-
• Tamoxifen (E)
• cis-Tamoxifen

Tamoxifen Citrate EP Impurity A ((E)-Tamoxifen)

CAS: 13002-65-8

Formula: C₂₆H₂₉NO

Color and Shape: White To Off-White Solid

Molecular weight: 371.52

Ref: 4Z-T-0110

Tamoxifen EP Impurity A

CAS: 13002-65-8

Formula: C₂₆H₂₉NO

Molecular weight: 371.52

Ref: ST-EA-CP-T40001

(E)-Tamoxifen

CAS: 13002-65-8

Formula: C₂₆H₂₉NO

Color and Shape: Neat

Molecular weight: 371.51

Ref: TR-T006010

(E)-Tamoxifen

Controlled Product

CAS: 13002-65-8

Tamoxifen is a drug that belongs to the group of antiestrogens. It is used in cancer treatment and is administered orally, intravenously, or by intramuscular injection. Tamoxifen has been shown to bind to estrogen receptors and inhibit the growth of estrogen-dependent breast cancer cells. Tamoxifen also has a number of metabolites, which are formed through reactions with reactive functional groups such as hydroxyl and cyano groups. These metabolites can be detected using magnetic resonance spectroscopy (MRS) and nuclear magnetic resonance (NMR). Some of these metabolites have been shown to have an effect on cell nuclei, including binding to DNA or altering the activity of enzymes involved in DNA synthesis.

Formula: C₂₆H₂₉NO

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 371.52 g/mol

Ref: 3D-FT27995

(E)-Tamoxifen-13C2, 15N

Controlled Product

CAS: 13002-65-8

Formula: C₂C₂₄H₂₉₁₅NO

Color and Shape: Neat

Molecular weight: 374.493

Ref: TR-T006012