CAS 130065-61-1

2-[3-(Diethylamino)propyl]-8,8-dipropyl-2-azaspiro[4.5]decane dihydrochloride

Description:

2-[3-(Diethylamino)propyl]-8,8-dipropyl-2-azaspiro[4.5]decane dihydrochloride, identified by its CAS number 130065-61-1, is a synthetic compound characterized by its complex spirocyclic structure, which includes a nitrogen atom in its framework, contributing to its classification as an azaspiro compound. This substance typically exhibits properties associated with tertiary amines due to the presence of the diethylamino group, which can influence its solubility and reactivity. The dihydrochloride form indicates that the compound is a salt, enhancing its stability and solubility in polar solvents, such as water. Its unique structure may impart specific biological activities, making it of interest in medicinal chemistry and pharmacology. The presence of multiple propyl groups suggests potential lipophilicity, which can affect its interaction with biological membranes. Overall, this compound's characteristics make it a subject of interest for research, particularly in the development of pharmaceuticals or as a chemical probe in biological studies.

Formula: C₂₂H₄₄N₂

InChI: InChI=1/C22H44N2/c1-5-10-21(11-6-2)12-14-22(15-13-21)16-19-24(20-22)18-9-17-23(7-3)8-4/h5-20H2,1-4H3

SMILES: CCCC1(CCC)CCC2(CC1)CCN(CCCN(CC)CC)C2

Synonyms:

• Atiprimod hydrochloride
• SK&F-106615-I2(dimaleate)
• Sk&F-106615-A2
• N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
• 3-(8,8-dipropyl-2-azaspiro[4.5]dec-2-yl)-N,N-diethylpropan-1-amine

Atiprimod Dihydrochloride

Controlled Product

CAS: 130065-61-1

Formula: C₂₂H₄₄N₂·2ClH

Color and Shape: Neat

Molecular weight: 409.52

Ref: TR-A790108

Atiprimod dihydrochloride

CAS: 130065-61-1

Atiprimod dihydrochloride is an investigational drug that belongs to a class of anti-infective agents called pyrazoles. Atiprimod binds to the Jak2 protein, which is associated with inflammatory bowel disease, and this binding causes cell death by apoptosis. This drug has been shown to cause eye disorders in animal models of ocular inflammation. It also inhibits epidermal growth factor (EGF) and can be used for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Atiprimod has been shown to inhibit tumour growth in breast cancer cells and leukemia cells. It also inhibits the production of pro-inflammatory cytokines by inhibiting protein synthesis at the mitochondrial membrane potential.

Formula: C₂₂H₄₆Cl₂N₂

Purity: Min. 95%

Molecular weight: 409.5 g/mol

Ref: 3D-FFA06561

Atiprimod dihydrochloride

CAS: 130065-61-1

JAK2 inhibitor; IC50=397 nM; hampers STAT3/5 phosphorylation; curbs growth and triggers apoptosis in JAK2V617F+ cells.

Formula: C₂₂H₄₆Cl₂N₂

Color and Shape: Solid

Molecular weight: 409.52

Ref: TM-T35894