CAS 13010-47-4

Lomustine

Description:

Lomustine, with the CAS number 13010-47-4, is a nitrosourea compound primarily used as an antineoplastic agent in cancer therapy. It is characterized by its ability to alkylate DNA, leading to cross-linking and subsequent inhibition of DNA replication and transcription, which ultimately induces cell death, particularly in rapidly dividing cancer cells. Lomustine is administered orally and is known for its lipophilic nature, allowing it to penetrate the blood-brain barrier, making it effective for treating brain tumors. The compound is typically used in combination with other chemotherapeutic agents and is associated with a range of side effects, including myelosuppression, nausea, and potential long-term risks such as secondary malignancies. Due to its potent effects and toxicity profile, careful monitoring of blood counts and patient response is essential during treatment. Lomustine's unique mechanism of action and its role in oncology highlight its significance in the therapeutic landscape for certain malignancies.

Formula: C₉H₁₆ClN₃O₂

InChI: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI key: InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N

SMILES: N(C(N(CCCl)N=O)=O)C1CCCCC1

Synonyms:

• (Chloro-2-Ethyl)-1-Cyclohexyl-3-Nitrosourea
• (Cloro-2-Etil)-1-Cicloesil-3-Nitrosourea
• 1-(2-Chloroethyl)-1-nitroso-3-cyclohexylurea
• 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitroso-Ure
• 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosoure
• 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
• 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
• 1-Chloro-3-Cyclohexyl-1-Ethyl-3-Nitrosourea
• 3-Cyclohexyl-1-(2-chloroethyl)-1-nitrosourea
• Belustine
• Ccnu
• Cecenu
• Ceenu
• Chloroethylcyclohexylnitrosourea
• Cinu
• Cyclohexylchloroethylnitrosourea
• Icig 1109
• Icig1109
• Lomtin
• Lomustin
• Lomustina
• Lustine
• Moostine
• N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
• N-(2-Chloroethyl)-N’-Cyclohexyl-N-Nitroso-Ure
• Nci-C04740
• Nsc-79037
• Nsc79037
• Rb 1509
• Rb1509
• Sri 2200
• Urea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-

Lomustine

CAS: 13010-47-4

Formula: C₉H₁₆ClN₃O₂

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 233.70

Ref: 3B-L0251

LOMUSTINE CRS

CAS: 13010-47-4

LOMUSTINE CRS

Formula: C₉H₁₆ClN₃O₂

Color and Shape: Powder

Molecular weight: 233.6952

Ref: 41-L0745000

Lomustine

CAS: 13010-47-4

Compounds with other nitrogen function, nesoi

Formula: C₉H₁₆ClN₃O₂

Color and Shape: Light Yellow Powder

Molecular weight: 233.0931

Ref: 45-1369419

Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

CAS: 13010-47-4

Formula: C₉H₁₆ClN₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 233.6952

Ref: IN-DA000U0T

Lomustine

CAS: 13010-47-4

Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.

Formula: C₉H₁₆ClN₃O₂

Purity: 98.36% - 99.44%

Color and Shape: Solid Solid

Molecular weight: 233.7

Ref: TM-T1601

Lomustine

CAS: 13010-47-4

Formula: C₉H₁₆ClN₃O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 233.70

Ref: 4Z-L-114001

Lomustine

CAS: 13010-47-4

Lomustine

Purity: ≥98%

Molecular weight: 233.7g/mol

Ref: 54-BUP16730

Lomustine

CAS: 13010-47-4

Formula: C₉H₁₆ClN₃O₂

Purity: ≥ 98.0%

Color and Shape: White to light-yellow powder

Molecular weight: 233.70

Ref: 7W-GP9057

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

CAS: 13010-47-4

Purity: 97.0%

Molecular weight: 233.6999969482422

Ref: 10-F036500

Lomustine - Bio-X ™

CAS: 13010-47-4

Lomustine is an alkylating agent that is used as chemotherapy for treating metastatic brain tumors and relapsed Hodgkin’s disease in combination with radiation treatments. This drug causes alkylation and cross-linking of DNA, thus inducing cytotoxicity. Furthermore, this drug inhibits DNA synthesis.

Formula: C₉H₁₆ClN₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 233.7 g/mol

Ref: 3D-BL164634

Lomustine

CAS: 13010-47-4

DNA cross linker

Formula: C₉H₁₆ClN₃O₂

Purity: Min. 95%

Color and Shape: White Slightly Yellow Powder

Molecular weight: 233.7 g/mol

Ref: 3D-FL24923

Lomustine

Controlled Product

CAS: 13010-47-4

Applications Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Johnston, T.P., et al.: J. Med. Chem., 9, 892 (1966), Oliverio, V.T., et al.: Cancer Res., 30, 1330 (1970), Thompson, G.R., et al.: Toxicol. Appl. Pharmacol., 21, 405 (1972), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 315 (1990),

Formula: C₉H₁₆ClN₃O₂

Color and Shape: Neat

Molecular weight: 233.70

Ref: TR-L469440