CAS 13010-47-4: Lomustine

Description: Lomustine, with the CAS number 13010-47-4, is a nitrosourea compound primarily used as an antineoplastic agent in cancer therapy. It is characterized by its ability to alkylate DNA, leading to cross-linking and subsequent inhibition of DNA replication and transcription, which ultimately induces cell death, particularly in rapidly dividing cancer cells. Lomustine is administered orally and is known for its lipophilic nature, allowing it to penetrate the blood-brain barrier, making it effective for treating brain tumors. The compound is typically used in combination with other chemotherapeutic agents and is associated with a range of side effects, including myelosuppression, nausea, and potential long-term risks such as secondary malignancies. Due to its potent effects and toxicity profile, careful monitoring of blood counts and patient response is essential during treatment. Lomustine's unique mechanism of action and its role in oncology highlight its significance in the therapeutic landscape for certain malignancies.

Formula: C₉H₁₆ClN₃O₂

InChI: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI key: InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N

SMILES: O=NN(C(=O)NC1CCCCC1)CCCl

Synonyms:

• (Chloro-2-Ethyl)-1-Cyclohexyl-3-Nitrosourea
• (Cloro-2-Etil)-1-Cicloesil-3-Nitrosourea
• 1-(2-Chloroethyl)-1-nitroso-3-cyclohexylurea
• 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitroso-Ure
• 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosoure
• 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
• 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
• 1-Chloro-3-Cyclohexyl-1-Ethyl-3-Nitrosourea
• 3-Cyclohexyl-1-(2-chloroethyl)-1-nitrosourea
• Belustine
• Ccnu
• Cecenu
• Ceenu
• Chloroethylcyclohexylnitrosourea
• Cinu
• Cyclohexylchloroethylnitrosourea
• Icig 1109
• Icig1109
• Lomtin
• Lomustin
• Lomustina
• Lustine
• Moostine
• N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
• N-(2-Chloroethyl)-N’-Cyclohexyl-N-Nitroso-Ure
• Nci-C04740
• Nsc-79037
• Nsc79037
• Rb 1509
• Rb1509
• Sri 2200
• Urea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-
• Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

Lomustine

CAS: 13010-47-4

• Formula: C₉H₁₆ClN₃O₂
• Purity: >98.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 233.70

Lomustine CRS

CAS: 13010-47-4

• Formula: C₉H₁₆ClN₃O₂
• Color and Shape: Powder
• Molecular weight: 233.6952

Lomustine

CAS: 13010-47-4

Compounds with other nitrogen function, nesoi

• Formula: C₉H₁₆ClN₃O₂
• Color and Shape: Light Yellow Powder
• Molecular weight: 233.0931

Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

CAS: 13010-47-4

• Formula: C₉H₁₆ClN₃O₂
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 233.6952

Lomustine

CAS: 13010-47-4

Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.

• Formula: C₉H₁₆ClN₃O₂
• Purity: 98.36% - 99.44%
• Color and Shape: Solid Solid
• Molecular weight: 233.7

Lomustine

CAS: 13010-47-4

• Formula: C₉H₁₆ClN₃O₂
• Purity: ≥ 98.0%
• Color and Shape: White to light-yellow powder
• Molecular weight: 233.70

Lomustine

CAS: 13010-47-4

• Purity: ≥98%
• Molecular weight: 233.7g/mol

Lomustine

CAS: 13010-47-4

• Formula: C₉H₁₆ClN₃O₂
• Color and Shape: Pale Yellow Solid
• Molecular weight: 233.70

Lomustine

CAS: 13010-47-4

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Color and Shape: Light yellow to yellow, Powder

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

CAS: 13010-47-4

• Purity: 97.0%
• Molecular weight: 233.6999969482422

Lomustine - Bio-X ™

CAS: 13010-47-4

Lomustine is an alkylating agent that is used as chemotherapy for treating metastatic brain tumors …

• Formula: C₉H₁₆ClN₃O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 233.7 g/mol

Lomustine

CAS: 13010-47-4

DNA cross linker

• Formula: C₉H₁₆ClN₃O₂
• Purity: Min. 95%
• Color and Shape: White Slightly Yellow Powder
• Molecular weight: 233.7 g/mol

Lomustine

CAS: 13010-47-4

Applications Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic. Not a …

• Formula: C₉H₁₆ClN₃O₂
• Color and Shape: Neat
• Molecular weight: 233.70