CAS 130104-32-4

Eberconazole nitrate

Description:

Eberconazole nitrate is an antifungal agent primarily used in the treatment of dermatological infections. It belongs to the class of imidazole derivatives and exhibits broad-spectrum activity against various fungi, including dermatophytes and yeasts. The compound functions by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting their integrity and leading to cell death. Eberconazole is typically formulated as a topical cream or solution, allowing for localized treatment with minimal systemic absorption. Its efficacy is complemented by a favorable safety profile, making it suitable for use in various patient populations, including those with sensitive skin. The compound is characterized by its relatively low toxicity and good tolerability, although, like all medications, it may cause localized irritation or allergic reactions in some individuals. Overall, Eberconazole nitrate represents an important therapeutic option in the management of superficial fungal infections.

Formula: C₁₈H₁₄Cl₂N₂·HNO₃

InChI: InChI=1S/C18H14Cl2N2.HNO3/c19-14-9-13-6-5-12-3-1-2-4-15(12)18(17(13)16(20)10-14)22-8-7-21-11-22;2-1(3)4/h1-4,7-11,18H,5-6H2;(H,2,3,4)

InChI key: InChIKey=DPHMSVRBAXJSPF-UHFFFAOYSA-N

SMILES: ClC1=C2C(C=3C(CCC2=CC(Cl)=C1)=CC=CC3)N4C=CN=C4.N(=O)(=O)O

Synonyms:

• 1H-Imidazole, 1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-, mononitrate
• Eberconazole nitrate
• 1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-1H-imidazole nitrate (1:1)
• 1H-Imidazole, 1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-, nitrate (1:1)

1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-1H-imidazole nitrate (1:1)

CAS: 130104-32-4

Formula: C₁₈H₁₅Cl₂N₃O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 392.2360

Ref: IN-DA000U0L

Eberconazole Nitrate

CAS: 130104-32-4

Eberconazole Nitrate

Purity: ≥98%

Molecular weight: 392.23g/mol

Ref: 54-BUP05743

Eberconazole Nitrate

CAS: 130104-32-4

Eberconazole Nitrate (Ebernet) is an azole antifungal agent and broad-spectrum imidazole derivative.

Formula: C₁₈H₁₅Cl₂N₃O₃

Purity: 99.53%

Color and Shape: Solid

Molecular weight: 392.23

Ref: TM-T7824

Eberconazole Nitrate

CAS: 130104-32-4

Formula: C₁₈H₁₄Cl₂N₂·HNO₃

Molecular weight: 329.22 63.01

Ref: 4Z-E-129001

Eberconazole Nitrate

Controlled Product

CAS: 130104-32-4

Formula: C₁₈H₁₄Cl₂N₂•HNO₃

Color and Shape: Neat

Molecular weight: 329.22 + 63.01

Ref: TR-E320020

1-(2,4-Dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole mononitrate

CAS: 130104-32-4

1-(2,4-Dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole mononitrate is an antifungal agent that is used in pharmaceutical dosage. It has been shown to have a constant activity against Trichophyton mentagrophytes and T. rubrum. 1-(2,4-Dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5) -1H-imidazole mononitrate has been shown to be a potent inhibitor of the fungal enzyme 14 alpha demethylase (14αDM). The inhibition of this enzyme leads to the accumulation of 14 alpha methylated sterols, which are toxic for the fungi and lead to cell death. The inhibition of 14

Formula: C₁₈H₁₄Cl₂N₂·HNO₃

Purity: Min. 95%

Molecular weight: 392.24 g/mol

Ref: 3D-FD159665